Professor, Pathology, University of Utah School of Medicine
Pathology
Dr. Carl T. Wittwer, MD
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Carl Wittwer works in the field of Pathology. He studied medicine at University of Michigan Medical School. Carl Wittwer has written publications. He has 100 publications published with PubMed. The lastest paper is: 'Prevention of adverse clinical outcome by monitoring of cardiac transplant patients for murine monoclonal CD3 antibody (OKT3) sensitization.'
Publications
- Copy Number Assessment by Competitive PCR with Limiting Deoxynucleotide Triphosphates and High-Resolution Melting.
- Molecular diagnostics: a revolution in progress.
- Rare event counting of CD59- red cells in human blood: A 47-month experience using PNH consensus guidelines for WBC and RBC testing in a reference lab.
- Extreme PCR: Efficient and Specific DNA Amplification in 15-60 Seconds.
- Quasi-digital PCR: Enrichment and quantification of rare DNA variants.
- Genotyping Accuracy of High-Resolution DNA Melting Instruments.
- The Influence of Nucleotide Sequence and Temperature on the Activity of Thermostable DNA Polymerases.
- Heterozygote PCR Product Melting Curve Prediction.
- Fluorescence-Based Temperature Control for PCR.
- Influence of PCR Reagents on DNA Polymerase Extension Rates Measured on Real-Time PCR Instruments.
- Quantum Method for Fluorescence Background Removal in DNA Melting Analysis.
- Stopped-flow DNA polymerase assay by continuous monitoring of dNTP incorporation by fluorescence.
- Symmetric Snapback Primers for Scanning and Genotyping of the Cystic Fibrosis Transmembrane Conductance Regulator Gene.
- Monitoring temperature with fluorescence during real-time PCR and melting analysis.
- uAnalyze: Web-Based High Resolution DNA Melting Analysis with Comparison to Thermodynamic Predictions.
- Advancing Laboratory Medicine through Innovation: A Tale of Six Inventors.
- Detecting and resolving position-dependent temperature effects in real-time quantitative polymerase chain reaction.
- Snapback Primer Genotyping of the Gilbert Syndrome UGT1A1 (TA)n Promoter Polymorphism by High-Resolution Melting.
- Detecting rare thrombophilia variants by high-resolution melting.
- Primer Sequence Disclosure: A Clarification of the MIQE Guidelines.
- Automated DNA extraction, quantification, dilution, and PCR preparation for genotyping by high-resolution melting.
- Making DNA melting useful.
- Rapid genetic analysis of x-linked chronic granulomatous disease by high-resolution melting.
- Enrichment and detection of rare alleles by means of snapback primers and rapid-cycle PCR.
- High resolution melting analysis for gene scanning.
- Rapid molecular analysis of the STAT3 gene in Job syndrome of hyper-IgE and recurrent infectious diseases.
- Spinning disk platform for microfluidic digital polymerase chain reaction.
- A rapid and efficient method of genotyping zebrafish mutants.
- RET mutation scanning update: exon 15.
- Human papillomavirus genotyping using an automated film-based chip array.
- Multiplex amplicon genotyping by high-resolution melting.
- High-resolution DNA melting analysis: advancements and limitations.
- Family clusters of variant X-linked chronic granulomatous disease.
- Multiple endocrine neoplasia type 2 RET protooncogene database: repository of MEN2-associated RET sequence variation and reference for genotype/phenotype correlations.
- The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments.
- Molecular diagnostics: at the cutting edge of translational research.
- Spatial DNA melting analysis for genotyping and variant scanning.
- LightCycler technology in molecular diagnostics.
- Mathematical algorithms for high-resolution DNA melting analysis.
- Snapback primer genotyping with saturating DNA dye and melting analysis.
- High resolution melting applications for clinical laboratory medicine.
- The use of EGFR exon 19 and 21 unlabeled DNA probes to screen for activating mutations in non-small cell lung cancer.
- Rapid diagnosis of MEN2B using unlabeled probe melting analysis and the LightCycler 480 instrument.
- Quadruplex genotyping of F5, F2, and MTHFR variants in a single closed tube by high-resolution amplicon melting.
- Scanning the cystic fibrosis transmembrane conductance regulator gene using high-resolution DNA melting analysis.
- Unlabeled probes for the detection and typing of herpes simplex virus.
- Expanded instrument comparison of amplicon DNA melting analysis for mutation scanning and genotyping.
- Identifying common genetic variants by high-resolution melting.
- Unlabeled oligonucleotides as internal temperature controls for genotyping by amplicon melting.
- Characterization of aberrant melting peaks in unlabeled probe assays.
- Solution-phase DNA mutation scanning and SNP genotyping by nanoliter melting analysis.
- RET proto-oncogene genotyping using unlabeled probes, the masking technique, and amplicon high-resolution melting analysis.
- Instrument comparison for heterozygote scanning of single and double heterozygotes: a correction and extension of Herrmann et al., Clin Chem 2006;52:494-503.
- Multiplex single-color PCR with amplicon melting analysis for identification of Aspergillus species.
- Evaluation of Her-2/neu gene status in osteosarcoma by fluorescence in situ hybridization and multiplex and monoplex polymerase chain reactions.
- Masking selected sequence variation by incorporating mismatches into melting analysis probes.
- Amplicon DNA melting analysis for mutation scanning and genotyping: cross-platform comparison of instruments and dyes.
- Mutation scanning of the RET protooncogene using high-resolution melting analysis.
- Real-time polymerase chain reaction and melting curve analysis.
- Quantitative heteroduplex analysis for single nucleotide polymorphism genotyping.
- Unlabeled oligonucleotide probes modified with locked nucleic acids for improved mismatch discrimination in genotyping by melting analysis.
- Molecular classification of melanoma using real-time quantitative reverse transcriptase-polymerase chain reaction.
- High-resolution DNA melting analysis for simultaneous mutation scanning and genotyping in solution.
- A comparison of high-resolution melting analysis with denaturing high-performance liquid chromatography for mutation scanning: cystic fibrosis transmembrane conductanc...
- Distinguishing different DNA heterozygotes by high-resolution melting.
- Fifty years of molecular (DNA/RNA) diagnostics.
- Rapid species identification within the Mycobacterium chelonae-abscessus group by high-resolution melting analysis of hsp65 PCR products.
- Sensitivity and specificity of single-nucleotide polymorphism scanning by high-resolution melting analysis.
- Single-tube method for nucleic acid extraction, amplification, purification, and sequencing.
- Genotyping hepatitis C virus by heteroduplex mobility analysis using temperature gradient capillary electrophoresis.
- Closed-tube genotyping with unlabeled oligonucleotide probes and a saturating DNA dye.
- Detection of c-kit-activating mutations in gastrointestinal stromal tumors by high-resolution amplicon melting analysis.
- Comparison of two quantitative polymerase chain reaction methods for detecting HER2/neu amplification.
- High-resolution genotyping by amplicon melting analysis using LCGreen.
- Amplicon melting analysis with labeled primers: a closed-tube method for differentiating homozygotes and heterozygotes.
- Real-time PCR technology for cancer diagnostics.
- Homogeneous amplification and mutation scanning of the p53 gene using fluorescent melting curves.
- Mapping quantitative trait loci for osteochondrosis in fetlock and hock joints and palmar/plantar osseus fragments in fetlock joints of South German Coldblood horses.
- Radioimmunoassay for pantothenic acid in blood and other tissues.
- Genetic parameters for the prevalence of osteochondrosis in the limb joints of South German Coldblood horses.
- Radiation hybrid mapping of equine CDK2, DGKA, DNAJC14, MMP19, CTSL and GAS1.
- Prevalence of osteochondrosis in the limb joints of South German Coldblood horses.
- A study to demonstrate freedom from Trichinella spp. in domestic pigs in Switzerland.
- [3 nursing studies about activities in a psychiatric hospital. III. My activities in rehabilitation].
- Use of the polymerase chain reaction in the diagnosis of ocular disease.
- Flow cytometry: principles and clinical applications in hematology.
- Prevention of adverse clinical outcome by monitoring of cardiac transplant patients for murine monoclonal CD3 antibody (OKT3) sensitization.
- HLA-B27 screening by flow cytometry.
- Assay of the enzymatic hydrolysis of pantetheine.
- Evaluation of electronic microarrays for genotyping factor V, factor II, and MTHFR.
- Hepatitis C genotyping by denaturing high-performance liquid chromatography.
- HLA-B27 typing: evaluation of an allele-specific PCR melting assay and two flow cytometric antigen assays.
- Genotyping of single-nucleotide polymorphisms by high-resolution melting of small amplicons.
- Nucleotide extension genotyping by high-resolution melting.
- Flow-induced thermal effects on spatial DNA melting.
- SNP genotyping by unlabeled probe melting analysis.
- Product differentiation during continuous-flow thermal gradient PCR.
- Genotyping of human platelet antigens 1 to 6 and 15 by high-resolution amplicon melting and conventional hybridization probes.
- Molecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH).
Schools
University Of Michigan Medical School
University of Utah
Doctors Specialties
- Pathology
Accepted Insurances
Education
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University of Utah -
University of Michigan Medical School
Hospital
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University of Utah Health Care - Hospital and Clinics
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