Dean, Emory University School of Medicine; Vice President Health Center Integration; Chairman, Emory Clinic
General Surgery
Dr. Christian P. Larsen, MD
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Doctor Christian P. Larsen, MD is an expert in the field of General Surgery. He studied medicine at Emory University School of Medicine. Emory University School of Medicine has a rank of 23 in research and a 42 in primary care He received 3 awards: "Elected Member", "Fellow (FACS)" and "Super Doctor". Christian P. Larsen is also published. He has 100 publications published. The lastest publication: "Low-Affinity Memory CD8+ T Cells Mediate Robust Heterologous Immunity.'
Publications
- Low-Affinity Memory CD8+ T Cells Mediate Robust Heterologous Immunity.
- Ebola Virus Disease: Experience and Decision Making for the First Patients outside of Africa.
- In vivo T cell costimulation blockade with abatacept for acute graft-versus-host Disease prevention: a first-in-Disease trial.
- Belatacept and sirolimus prolong nonhuman primate islet allograft survival: adverse consequences of concomitant alefacept therapy.
- A novel monoclonal antibody to CD40 prolongs islet allograft survival.
- Alternative immunomodulatory strategies for xenotransplantation: CD40/154 pathway-sparing regimens promote xenograft survival.
- Evidence for kidney rejection after combined bone marrow and renal transplantation despite ongoing whole-blood chimerism in rhesus macaques.
- CTLA4Ig prevents alloantibody formation following nonhuman primate islet transplantation using the CD40-specific antibody 3A8.
- Regulatory T cells exhibit decreased proliferation but enhanced suppression after pulsing with sirolimus.
- The impact of renal function on outcomes of bariatric surgery.
- Immunogenetic Management Software: a new tool for visualization and analysis of complex immunogenetic datasets.
- Nonhuman primate transplant models finally evolve: detailed immunogenetic analysis creates new models and strengthens the old.
- Cumulative Exposure to Gamma Interferon-Dependent Chemokines CXCL9 and CXCL10 Correlates with Worse Outcome After Lung Transplant.
- Three-year outcomes from BENEFIT, a randomized, active-controlled, parallel-group study in adult kidney transplant recipients.
- Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8(+) memory T cells.
- CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model.
- Nondepleting anti-CD40-based therapy prolongs allograft survival in nonhuman primates.
- Cumulative exposure to CD8+ granzyme Bhi T cells is associated with reduced lung function early after lung transplantation.
- Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade.
- Islet xenotransplantation using gal-deficient neonatal donors improves engraftment and function.
- LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function.
- Glial Cell Line-Derived Neurotrophic Factor Enhances Human Islet Posttransplantation Survival.
- Transplantation tolerance: memories that haunt us.
- Miles to go....
- Belatacept-based regimens are associated with improved cardioVascular and metabolic risk factors compared with cyclosporine in kidney transplant recipients (BENEFIT an...
- CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates.
- Regulatory T cells in lung transplantation--an emerging concept.
- Pillars article: long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature. 1996. 381: 434-438. 1996.
- Limiting the amount and duration of antigen exposure during priming increases memory T cell requirement for costimulation during recall.
- Selective targeting of human alloresponsive CD8+ effector memory T cells based on CD2 expression.
- Belatacept-based regimens versus a cyclosporine A-based regimen in kidney transplant recipients: 2-year results from the BENEFIT and BENEFIT-EXT studies.
- An integrated safety profile analysis of belatacept in kidney transplant recipients.
- CD28 blockade induces division-dependent downregulation of interleukin-2 receptor alpha.
- GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T cells as a reservoir of breakthrough T-cell proliferation ...
- LFA-1-specific therapy prolongs allograft survival in rhesus macaques.
- An MHC-defined primate model reveals significant rejection of bone marrow after mixed chimerism induction despite full MHC matching.
- Pathogenic virus-specific T cells cause Disease during treatment with the calcineurin inhibitor FK506: implications for transplantation.
- Surgical correction of gastroesophageal reflux in lung transplant patients is associated with decreased effector CD8 cells in lung lavages: a case series.
- Experience with a novel efalizumab-based immunosuppressive regimen to facilitate single donor islet cell transplantation.
- Five-year safety and efficacy of belatacept in renal transplantation.
- Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses.
- Overcoming the memory barrier in tolerance induction: molecular mimicry and functional heterogeneity among pathogen-specific T-cell populations.
- Cellular localization of epidermal-type and brain-type fatty acid-binding proteins in adult hippocampus and their response to cerebral ischemia.
- High-frequency alloreactive T cells augment effector function of low-frequency CD8+ T-cell responses under CD28/CD154 blockade.
- Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling.
- Decreased incidence of NSF in patients on dialysis after changing gadolinium contrast-enhanced MRI protocols.
- Dynamics of human regulatory T cells in lung lavages of lung transplant recipients.
- Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation.
- Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates.
- Donor-reactive T-cell stimulation history and precursor frequency: barriers to tolerance induction.
- IFN-gamma dictates allograft fate via opposing effects on the graft and on recipient CD8 T cell responses.
- Expanded nonhuman primate tregs exhibit a unique gene expression signature and potently downregulate alloimmune responses.
- PD-1-dependent mechanisms maintain Peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue.
- CD28/CD154 blockade prevents autoimmune diabetes by inducing nondeletional tolerance after effector t-cell inhibition and regulatory T-cell expansion.
- A critical precursor frequency of donor-reactive CD4+ T cell help is required for CD8+ T cell-mediated CD28/CD154-independent rejection.
- Expansion of effector memory TCR Vbeta4+ CD8+ T cells is associated with latent infection-mediated resistance to transplantation tolerance.
- Glial cell line-derived neurotrophic factor increases beta-cell mass and improves glucose tolerance.
- Belatacept and basiliximab diminish human antiporcine xenoreactivity and synergize to inhibit alloimmunity.
- Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection.
- Role of CD28 in fatal autoimmune disorder in scurfy mice.
- Fully MHC-disparate mixed hemopoietic chimeras show specific defects in the control of chronic viral infections.
- Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques.
- Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation.
- Induction of chimerism in rhesus macaques through stem cell transplant and costimulation blockade-based immunosuppression.
- Alloimmunity: no toll exemption.
- Apoptotic donor leukocytes limit mixed-chimerism induced by CD40-CD154 blockade in allogeneic bone marrow transplantation.
- Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection.
- Toward transplantation tolerance: a large step on a long road.
- Infection in renal transplantation: a case of acute Q fever.
- Tolerance assays: measuring the unknown.
- A mouse model for polyomavirus-associated nephropathy of kidney transplants.
- Transplant tolerance in non-human primates: progress, current challenges and unmet needs.
- A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression.
- Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways.
- Patients, pathogens, and protective immunity: the relevance of virus-induced alloreactivity in transplantation.
- Immunosuppressive and trafficking properties of donor splenic and bone marrow dendritic cells.
- Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection.
- NK cells mediate costimulation blockade-resistant rejection of allogeneic stem cells during nonmyeloablative transplantation.
- Transplant tolerance: converging on a moving target.
- Late priming and variability of epitope-specific CD8+ T cell responses during a persistent virus infection.
- Impaired recall of CD8 memory T cells in immunologically privileged tissue.
- Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival.
- Induction of chimerism and tolerance using freshly purified or cultured hematopoietic stem cells in nonmyeloablated mice.
- Blockade of T cell costimulation reveals interrelated actions of CD4+ and CD8+ T cells in control of SIV replication.
- Chimerism and cure: hematologic and pathologic correction of murine sickle cell Disease.
- Intravital microscopy identifies selectins that regulate T cell traffic into allografts.
- Heterologous immunity provides a potent barrier to transplantation tolerance.
- Induction of operational tolerance to discordant dopaminergic porcine xenografts.
- Islet transplantation, stem cells, and transfusion medicine.
- Primary and secondary immunocompetence in mixed allogeneic chimeras.
- Cutting edge: persistent viral infection prevents tolerance induction and escapes immune control following CD28/CD40 blockade-based regimen.
- Anti-CD40 therapy extends renal allograft survival in rhesus macaques.
- Prevention of chronic rejection in murine cardiac allografts: a comparison of chimerism- and nonchimerism-inducing costimulation blockade-based tolerance induction reg...
- SVR angiosarcomas can be rejected by CD4 costimulation dependent and CD8 costimulation independent pathways.
- Anti-lymphocyte function-associated antigen-1 monoclonal antibody inhibits CD40 ligand-independent immune responses and prevents chronic vasculopathy in CD40 ligand-de...
- Dynamic regulation of T cell immunity by CD43.
- A cure for murine sickle cell Disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-m...
- Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates.
- The role of the IL-2 pathway in costimulation blockade-resistant rejection of allografts.
Schools
Emory University
Stanford University School Med
Emory University Affiliated Hospitals Residency Program
Emory University Hospital
Woodruff Health Sciences Center Emory University Vice President Health Center Integration
Procedures Preformed
- Port Placements or Replacements
- Renal Transplant and Nephrectomy
Conditions Treated
- Diaphragmatic and-or Hiatal Hernia
- Hemorrhoids
- Hyperparathyroidism
- Peripheral Vascular Disease (PAD, PVD)
Doctors Specialties
- General Surgery
Accepted Insurances
Awards
- Elected Member
- Fellow (FACS)
- Super Doctor
Education
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Emory University -
Stanford University -
Emory University School of Medicine
Hospital
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Emory University Hospital -
Children's Healthcare of Atlanta -
Emory University Hospital Midtown -
Grady Memorial Hospital
Drug Facts
| NPI NUMBER | 1851341614 | |
| NPPES Provider LastName | LARSEN | |
| NPPES Provider FirstName | CHRISTIAN | |
| NPPES Provider ZIPCode | 30322 | |
| NPPES Provider State | GA | |
| Specialty Description | General Surgery | |
| Total Claim Count | 74.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1851341614 |
| Last Name Of The Provider | LARSEN |
| First Name Of The Provider | CHRISTIAN |
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