Professor, Pathology and Laboratory Medicine, Emory University School of Medicine
Pathology
Dr. Daniel J. Brat, MD
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Doctor Daniel J. Brat, MD is an expert in the field of Pathology. He researched medicine at Mayo Medical School. Mayo Medical School is ranked 27/42 in Research/PrimaryCare. He received 2 awards: "Top MD" and "Super Doctor". Doctor Daniel J. Brat, MD is also a published doctor. He has 100 paper published. The most recent paper is: Phase 2 study of concurrent radiotherapy and temozolomide followed by temozolomide and lomustine in the treatment of children with high-grade glioma: a report of the C... Daniel Brat is registered with Medicare and accepts Medicare payments.
Publications
- Biomarker-driven diagnosis of diffuse gliomas.
- 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
- Management of patients with recurrence of diffuse low grade glioma : A systematic review and evidence-based clinical practice guideline.
- Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution.
- Template for Reporting Results of Biomarker Testing of Specimens From Patients With Tumors of the Central Nervous System.
- Novel genotype-phenotype associations in human cancers enabled by advanced molecular platforms and computational analysis of whole slide images.
- Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody.
- Analysis of graft survival in a trial of stem cell transplant in ALS.
- Cancer Stem Cell Division: When the Rules of Asymmetry are Broken.
- Lysine Acetylation Activates 6-Phosphogluconate Dehydrogenase to Promote Tumor Growth.
- International Society of Neuropathology-Haarlem Consensus Guidelines, for Nervous System Tumor Classification and Grading.
- The role of neuropathology in the management of progressive glioblastoma : A systematic review and evidence-based clinical practice guideline.
- Outcomes and patterns of failure for grade 2 meningioma treated with reduced-margin intensity modulated radiation therapy.
- Real-Time Magnetic Resonance-Guided Stereotactic Laser Amygdalohippocampotomy for Mesial Temporal Lobe Epilepsy.
- The modern pathologist: lab data deliverer, interpreter, and diagnostician.
- Merlin sumoylation is required for its tumor suppressor activity.
- Glioblastoma with oligodendroglioma component (GBM-O): molecular genetic and clinical characteristics.
- Cancer Digital Slide Archive: an informatics resource to support integrated in silico analysis of TCGA pathology data.
- Diffuse Leptomeningeal Neuroepithelial Tumor: 9 Pediatric Cases With Chromosome 1p/19q Deletion Status and IDH1 (R132H) Immunohistochemistry.
- Genomic Mapping and Survival Prediction in Glioblastoma: Molecular Subclassification Strengthened by Hemodynamic Imaging Biomarkers.
- Diagnostic implications of IDH1-R132H and OLIG2 expression patterns in rare and challenging glioblastoma variants.
- Reactive retinal astrocytic tumors (so-called vasoproliferative tumors): histopathologic, immunohistochemical, and genetic studies of four cases.
- MR Imaging Predictors of Molecular Profile and Survival: Multi-institutional Study of the TCGA Glioblastoma Data Set.
- PDGFRA Amplification is Common in Pediatric and Adult High-Grade Astrocytomas and Identifies a Poor Prognostic Group in IDH1 Mutant Glioblastoma.
- Pituitary Carcinoma in Situ.
- Silent Corticotroph Adenomas: Emory University Cohort and Comparison With ACTH-Negative Nonfunctioning Pituitary Adenomas.
- Lectins Identify Glycan Biomarkers on Glioblastoma-Derived Cancer Stem Cells.
- Digital Pathology: Data-Intensive Frontier in Medical Imaging: Health-information sharing, specifically of digital pathology, is the subject of this paper which discus...
- The Tumor Microenvironment Strongly Impacts Master Transcriptional Regulators and Gene Expression Class of Glioblastoma.
- Glioblastoma occurring at the site of a previous medulloblastoma following a 5-year remission period.
- Integrative, Multimodal Analysis of Glioblastoma Using TCGA Molecular Data, Pathology Images, and Clinical Outcomes.
- Metabolomic Profiling Reveals Potential Markers and Bioprocesses Altered in Bladder Cancer Progression.
- Progesterone Inhibits the Growth of Human Neuroblastoma: In Vitro and In Vivo Evidence.
- MORPHOLOGICAL SIGNATURES AND GENOMIC CORRELATES IN GLIOBLASTOMA.
- Temozolomide in the treatment of high-grade gliomas in children: a report from the Children's Oncology Group.
- Erratum to: Cancer susceptibility variants and the risk of adult glioma in a US case-control study.
- Cancer susceptibility variants and the risk of adult glioma in a US case-control study.
- Metastasis Infiltration: An Investigation of the Postoperative Brain-Tumor Interface.
- An integrative approach for in silico glioma research.
- Magnetic resonance imaging features of pituicytomas: analysis of 10 cases.
- Discovery of a proneurogenic, neuroprotective chemical.
- Caffeine-mediated inhibition of calcium release channel inositol 1,4,5-trisphosphate receptor subtype 3 blocks glioblastoma invasion and extends survival.
- The proneural molecular signature is enriched in oligodendrogliomas and predicts improved survival among diffuse gliomas.
- Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma.
- De novo germline TP53 mutation presenting with synchronous malignancies of the central nervous system.
- Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 locali...
- Distinguishing chordoid meningiomas from their histologic mimics: an immunohistochemical evaluation.
- Management of newly diagnosed glioblastoma: guidelines development, value and application.
- Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity.
- Silencing of TMS1/ASC promotes resistance to anoikis in breast epithelial cells.
- Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor.
- Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism.
- Galectin-3 expression is ubiquitous in tumors of the sellar region, nervous system, and mimics: an immunohistochemical and RT-PCR study.
- Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses.
- Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4.
- Best cases from the AFIP: glioblastoma multiforme.
- An astroblastoma mimicking a cavernous malformation: case report.
- Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model.
- Attractin is elevated in the cerebrospinal fluid of patients with malignant astrocytoma and mediates glioma cell migration.
- Early growth response gene-1 regulates hypoxia-induced expression of tissue factor in glioblastoma multiforme through hypoxia-inducible factor-1-independent mechanisms.
- 'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis.
- The elusive origin of chordoid glioma.
- Proliferation (MIB-1 expression) in oligodendrogliomas: assessment of quantitative methods and prognostic significance.
- Clarifying the diffuse gliomas: an update on the morphologic features and markers that discriminate oligodendroglioma from astrocytoma.
- Upregulation of hypoxia inducible factor is associated with attenuation of neuronal injury in neonatal piglets undergoing deep hypothermic circulatory arrest.
- The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice.
- Spinal intradural clear cell meningioma following resection of a suprasellar clear cell meningioma. Case report and recommendations for management.
- Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis.
- The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis.
- Transgenic expression of dominant negative tuberin through a strong constitutive promoter results in a tissue-specific tuberous sclerosis phenotype in the skin and brain.
- PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma.
- Special lecture: glial reactivity after damage: implications for scar formation and neuronal recovery.
- Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumors.
- Notch1 and notch2 have opposite effects on embryonal brain tumor growth.
- Anaplastic meningioma versus meningeal hemangiopericytoma: immunohistochemical and genetic markers.
- Aberrant methylation and down-regulation of TMS1/ASC in human glioblastoma.
- Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes.
- Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma.
- Pituicytoma: report of two cases and clues regarding histogenesis.
- Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population.
- Primary central nervous system posttransplant lymphoproliferative disorders.
- 9p21 and 13q14 dosages in ependymomas. A clinicopathologic study of 101 cases.
- Fatal West Nile virus encephalitis in a renal transplant recipient.
- The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia.
- Differential expression of folate receptor in pituitary adenomas.
- Genetic markers in glioblastoma: prognostic significance and future therapeutic implications.
- Malignant glioma physiology: cellular response to hypoxia and its role in tumor progression.
- Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression.
- Ancillary FISH analysis for 1p and 19q status: preliminary observations in 287 gliomas and oligodendroglioma mimics.
- Genetic modulation of hypoxia induced gene expression and angiogenesis: relevance to brain tumors.
- Infiltrative astrocytomas with granular cell features (granular cell astrocytomas): a study of histopathologic features, grading, and outcome.
- Differential expression between pilocytic and anaplastic astrocytomas: identification of apolipoprotein D as a marker for low-grade, non-infiltrating primary CNS neopl...
- Astroblastoma: radiologic-pathologic correlation and distinction from ependymoma.
- Genetic and biologic progression in astrocytomas and their relation to angiogenic dysregulation.
- Blockade of Glioma Proliferation Through Allosteric Inhibition of JAK2.
- P53 tumor suppression network in cancer epigenetics.
- Machine-based morphologic analysis of glioblastoma using whole-slide pathology images uncovers clinically relevant molecular correlates.
- Tumor angiogenesis therapy using targeted delivery of Paclitaxel to the vasculature of breast cancer metastases.
- Phase 2 study of concurrent radiotherapy and temozolomide followed by temozolomide and lomustine in the treatment of children with high-grade glioma: a report of the C...
Schools
Mayo Medical School
Johns Hopkins University School Med
Doctors Specialties
- Neuropathology
- Pathology
Accepted Insurances
- Aetna
- Amerigroup (Wellpoint)
- Bakery & Confectionary Union Plan
- Cigna
- Commercial Insurance Company
- Coventry Health Care
- GEHA
- HealthPartners
- Humana
- Kaiser Permanente
- Medicare MCR
- POMCO Group
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
Awards
- Top MD
- Super Doctor
Education
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Johns Hopkins University -
Mayo Medical School
Hospital
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Emory University Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1982639001 |
| Last Name Of The Provider | BRAT |
| First Name Of The Provider | DANIEL |
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