Professor, Medicine, University of California Los Angeles David Geffen SOM
Gastroenterology
Dr. Daniel W. Hommes, MD
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Daniel W. Hommes, MD works in the field of Gastroenterology. Daniel Hommes is a published doctor and has 101 publications published. The lastest was: 'Stem cells: HSCT for Crohn's disease: work in progress or a bridge too far?'
Publications
- Stem cells: HSCT for Crohn's Disease: work in progress or a bridge too far?
- Anti-TNF-α therapies for the treatment of Crohn's Disease: the past, present and future.
- Diminished expression of CRHR2 in human colon cancer promotes tumor growth and EMT via persistent IL-6/Stat3 signaling.
- Classifying Back Pain and Peripheral Joint Complaints in Inflammatory Bowel Disease Patients: A Prospective Longitudinal Follow-up Study.
- A MicroRNA Signature in Pediatric Ulcerative Colitis: Deregulation of the miR-4284/CXCL5 Pathway in the Intestinal Epithelium.
- Value-Based Health Care for Inflammatory Bowel Diseases.
- How Does a Gastroenterologist Demonstrate Value?
- A nationwide 2010-2012 analysis of u.s. Health care utilization in inflammatory bowel Diseases.
- New tools and approaches for improved management of inflammatory bowel Diseases.
- IBD: Antibodies to anti-TNF therapy-consequences for IBD management.
- Stem cell therapy in inflammatory bowel Disease: which, when and how?
- Anti-TNF antibodies in Inflammatory Bowel Disease: do we finally know how it works?
- Mucosal schwann cell hamartoma in Ulcerative colitis: diagnosis and clinical relevance.
- Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro.
- Gene and cell therapy based treatment strategies for inflammatory bowel Diseases.
- Long-term follow-up of autologous hematopoietic stem cell transplantation for severe refractory Crohn''s Disease.
- Origin and functional activity of the membrane-bound glucocorticoid receptor.
- Neutralizing antibodies against adeno-associated viruses in inflammatory bowel Disease patients: implications for gene therapy.
- Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell ''stemness'' via the bone morphog...
- Pretreatment with interferon-γ enhances the therapeutic activity of mesenchymal stromal cells in animal models of Colitis.
- Mesenchymal stromal cell function is not affected by drugs used in the treatment of inflammatory bowel Disease.
- IBD and arthropathies: a practical approach to its diagnosis and management.
- Mannose-binding lectin and ficolin-2 gene polymorphisms predispose to cytomegalovirus (re)infection after orthotopic liver transplantation.
- Risk of malignant lymphoma in patients with inflammatory bowel Diseases: a Dutch nationwide study.
- Blimp1 regulates the transition of neonatal to adult Intestinal epithelium.
- Matrix metalloproteinase 2 genotype is associated with nonanastomotic biliary strictures after orthotopic liver transplantation.
- Evaluation of an MRI-based score of Disease activity in perianal fistulizing Crohn''s Disease.
- Intestinal tumorigenesis is not affected by progesterone signaling in rodent models.
- Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastroIntestinal cancer.
- Development of the Crohn's Disease digestive damage score, the Lémann score.
- Adalimumab for induction of clinical remission in moderately to severely active Ulcerative colitis: results of a randomised controlled trial.
- Malignant transformation of perianal and enterocutaneous fistulas is rare: results of 17 years of follow-up from The Netherlands.
- Magnetic resonance imaging surveillance detects early-stage pancreatic cancer in carriers of a p16-Leiden mutation.
- Anti-tumor necrosis factor-α antibodies induce regulatory macrophages in an Fc region-dependent manner.
- Histomorphometric analysis reveals reduced bone mass and bone formation in patients with quiescent Crohn''s Disease.
- Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn''s Disease: results of a phase I study.
- Phase I, double-blind, randomized, placebo-controlled, dose-escalation study of NI-0401 (a fully human anti-CD3 monoclonal antibody) in patients with moderate to sever...
- The joint-gut axis in inflammatory bowel Diseases.
- The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3 in colorectal cancer.
- Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn''s Disease.
- Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver transplantation.
- Ig-free light chains play a crucial role in murine mast cell-dependent colitis and are associated with human inflammatory bowel Diseases.
- A randomised placebo-controlled multicentre trial of intravenous semapimod HCl for moderate to severe Crohn''s Disease.
- Acromegaly is associated with an increased prevalence of colonic diverticula: a case-control study.
- 5-aminosalicylic acid interferes in the cell cycle of colorectal cancer cells and induces cell death modes.
- The second European evidence-based Consensus on the diagnosis and management of Crohn''s Disease: Current management.
- Anti-TNF and Crohn''s Disease: when should we start?
- Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in Disease risk.
- Mucosal healing predicts sustained clinical remission in patients with early-stage Crohn''s Disease.
- Fontolizumab in moderate to severe Crohn's Disease: a phase 2, randomized, double-blind, placebo-controlled, multiple-dose study.
- The exon-3 deleted growth hormone receptor polymorphism predisposes to long-term complications of acromegaly.
- Quality of web-based information on inflammatory bowel Diseases.
- Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel Disease.
- More right-sided IBD-associated colorectal cancer in patients with primary sclerosing cholangitis.
- Clinical significance of stromal apoptosis in colorectal cancer.
- 5-Aminosalicylic acid inhibits Colitis-associated but not sporadic colorectal neoplasia in a novel conditional Apc mouse model.
- Update on genetics in inflammatory Disease.
- Active TGF-beta1 correlates with myofibroblasts and malignancy in the colorectal adenoma-carcinoma sequence.
- Molecular prediction of Disease risk and severity in a large Dutch Crohn''s Disease cohort.
- First endoscopic appearance of Ulcerative colitis.
- Novel insights into mechanisms of glucocorticoid action and the development of new glucocorticoid receptor ligands.
- High frequency of early colorectal cancer in inflammatory bowel Disease.
- VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis.
- MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not.
- Dosing azathioprine in thiopurine S-methyltransferase deficient inflammatory bowel Disease patients.
- Stem cells as potential novel therapeutic strategy for inflammatory bowel Disease.
- The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers.
- Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn''s Disease: an open randomised trial.
- Muramyl dipeptide-induced differential gene expression in NOD2 mutant and wild-type Crohn''s Disease patient-derived dendritic cells.
- The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer.
- Are we ready for top-down therapy for inflammatory bowel Diseases: pro.
- Individualized population pharmacokinetic model with limited sampling for cyclosporine monitoring after liver transplantation in clinical practice.
- A phase I study of visilizumab, a humanized anti-CD3 monoclonal antibody, in severe steroid-refractory Ulcerative colitis.
- Fish oil for induction of remission in Ulcerative colitis.
- Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells.
- The effect of statins in colorectal cancer is mediated through the bone morphogenetic protein pathway.
- Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists.
- Bone morphogenetic protein signaling suppresses tumorigenesis at Gastric epithelial transition zones in mice.
- Tissue level, activation and cellular localisation of TGF-beta1 and association with survival in Gastric cancer patients.
- Increased mucosal matrix metalloproteinase-1, -2, -3 and -9 activity in patients with inflammatory bowel Disease and the relation with Crohn''s Disease phenotype.
- Biologics in Crohn''s Disease: searching indicators for outcome.
- Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-alpha single nucleotide gene polymorphisms in inflammatory bowel dise...
- Systematic review of dysplasia after restorative proctocolectomy for Ulcerative colitis.
- Glucocorticoid signaling: a nongenomic mechanism for T-cell immunosuppression.
- Narrow-band imaging compared with conventional colonoscopy for the detection of dysplasia in patients with longstanding Ulcerative colitis.
- Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel Disease.
- Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn''s Disease.
- Once daily MMX mesalazine for the treatment of mild-to-moderate Ulcerative colitis: a phase II, dose-ranging study.
- Critical appraisal of the current practice in murine TNBS-induced Colitis.
- Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN.
- Review article: thiopurines in inflammatory bowel Disease.
- Guidelines for treatment with infliximab for Crohn''s Disease.
- Biological therapy in the management of recent-onset Crohn''s Disease: why, when and how?
- A dose escalating, placebo controlled, double blind, single dose and multidose, safety and tolerability study of fontolizumab, a humanised anti-interferon gamma antibo...
- Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn''s Disease.
- Feasibility of evaluating Crohn''s Disease activity at 3.0 Tesla.
- Kinome analysis reveals nongenomic glucocorticoid receptor-dependent inhibition of insulin signaling.
- A role for STAT5 in steroid-resistant UC?
- Novel biological therapies for inflammatory bowel Disease.
- A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn''s Disease.
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
- Endoscopy (Esophagus, Stomach, Small Intestine)
Conditions Treated
- Anemia
- Crohn's Disease (Regional Enteritis)
- Diverticulosis, Intestinal
- Dysphagia
- View All
Doctors Specialties
- Gastroenterology
Accepted Insurances
Education
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University of Amsterdam Faculty of Medicine
Hospital
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Ronald Reagan UCLA Medical Center -
Santa Monica-UCLA Medical Center and Orthopaedic Hospital
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