Professor, Internal Medicine, University of Virginia School of Medicine
Endocrinology
Dr. Helmy M. Siragy, MD
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Helmy Siragy works in the field of Endocrinology. He received awards:"CMS Meaningful Use Stage 1 Certification". Helmy M. Siragy, MD is a published doctor and has 101 publications published. The lastest was: 'Differential regulation of renal angiotensin subtype AT1A and AT2 receptor protein in rats with angiotensin-dependent hypertension.' Doctor Helmy M. Siragy, MD accepts Medicare.
Publications
- (Pro)renin receptor contributes to regulation of renal epithelial sodium channel.
- High-fat diet amplifies renal renin angiotensin system expression, blood pressure elevation, and renal dysfunction caused by Ceacam1 null deletion.
- AT2 Receptor Activities and Pathophysiological Implications.
- A NONPEPTIDE ANGIOTENSIN II TYPE 2 RECEPTOR AGONIST PREVENTS RENAL INFLAMMATION IN EARLY DIABETES.
- REGULATION OF (PRO)RENIN RECEPTOR EXPRESSION IN mIMCD VIA GSK3β-NFAT5- SIRT-1 SIGNALING PATHWAY.
- Targeted Deletion of Murine CEACAM 1 Activates PI3K-Akt Signaling and Contributes to the Expression of (Pro)Renin Receptor via CREB Family and NF-κB Transcription Fact...
- Reduction of aldosterone production improves renal oxidative stress and fibrosis in diabetic rats.
- In vivo regulation of renal expression of (pro)renin receptor by a low-sodium diet.
- Sodium Depletion Enhances Renal Expression of (Pro)Renin Receptor via Cyclic GMP-Protein Kinase G Signaling Pathway.
- COMBINED ALISKIREN AND AMLODIPINE REDUCE ALBUMINURIA VIA REDUCTION IN RENAL INFLAMMATION IN DIABETIC RATS.
- To ACCELERATE Hypertension Control.
- Angiotensin II Type-2 Receptors Modulate Inflammation Through Signal Transducer and Activator of Transcription Proteins 3 Phosphorylation and TNFα Produc...
- Rationale for combining a direct renin inhibitor with other renin- angiotensin system blockers. Focus on aliskiren and combinations.
- Angiotensin ATâ‚‚ receptor stimulation inhibits early renal inflammation in renovascular hypertension.
- ESCAPE: From hypertension to renal failure.
- Regulation of (pro)renin receptor expression by glucose-induced mitogen-activated protein kinase, nuclear factor-kappaB, and activator protein-1 signaling pathways.
- Comparing angiotensin II receptor blockers on benefits beyond blood pressure.
- Glucose promotes the production of interleukine-1beta and cyclooxygenase-2 in mesangial cells via enhanced (Pro)renin receptor expression.
- The potential role of the angiotensin subtype 2 receptor in cardiovascular protection.
- ACCOMPLISH the goal: hypertension and beyond.
- Regulation of renal 12(S)-hydroxyeicosatetraenoic acid in diabetes by angiotensin AT1 and AT2 receptors.
- Evidence for benefits of angiotensin receptor blockade beyond blood pressure control.
- Extracellular renal guanosine cyclic 3'5'-monophosphate modulates nitric oxide and pressure-induced natriuresis.
- NO and cGMP mediate angiotensin AT2 receptor-induced renal renin inhibition in young rats.
- Renin inhibition: a new modality for hypertension management.
- TROPHY for preventing hypertension.
- Intrarenal aminopeptidase N inhibition augments natriuretic responses to angiotensin III in angiotensin type 1 receptor-blocked rats.
- Angiotensin II type 2 receptor-bradykinin B2 receptor functional heterodimerization.
- Does pharmacologic weight reduction improve blood pressure?
- Hyponatremia, fluid-electrolyte disorders, and the syndrome of inappropriate antidiuretic hormone secretion: diagnosis and treatment options.
- Beneficial effects of combined benazepril-amlodipine on cardiac nitric oxide, cGMP, and TNF-alpha production after cardiac ischemia.
- Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat.
- Local renal aldosterone system and its regulation by salt, diabetes, and angiotensin II type 1 receptor.
- Clinical trials report. Beta-blockade in diabetes: alleviating the concerns.
- Increased renal production of angiotensin II and thromboxane B2 in conscious diabetic rats.
- Angiotensin subtype-2 receptors inhibit renin biosynthesis and angiotensin II formation.
- Clinical trials report. VALIANT: another milestone for angiotensin receptor blockers.
- Genetic markers: progress and potential for cardiovascular disease.
- Renal interstitial guanosine cyclic 3', 5'-monophosphate mediates pressure-natriuresis via protein kinase G.
- AT1 and AT2 receptor in the kidney: role in health and disease.
- Production and role of extracellular guanosine cyclic 3', 5' monophosphate in sodium uptake in human proximal tubule cells.
- Angiotensin AT2 receptors directly stimulate renal nitric oxide in bradykinin B2-receptor-null mice.
- Urinary and renal interstitial concentrations of TNF-alpha increase prior to the rise in albuminuria in diabetic rats.
- Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertension.
- Molality as a unit of measure for expressing 1H MRS brain metabolite concentrations in vivo.
- Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitors or calcium channel blocker vs diuretic. The Antihypertensive a...
- The intrarenal renin-angiotensin system and diabetic nephropathy.
- The angiotensin II type 1 receptor mediates renal interstitial content of tumor necrosis factor-alpha in diabetic rats.
- Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation.
- Angiotensin receptor blockers: how important is selectivity?
- Constrained modeling for spectroscopic measurement of bi-exponential spin-lattice relaxation of water in vivo.
- The choice of antihypertensive drugs in patients with diabetes: angiotensin II and beyond.
- American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of hypertension.
- Angiotensin II compartmentalization within the kidney: effects of salt diet and blood pressure alterations.
- Angiotensin AT1 and AT2 receptors--the battle for health and disease.
- Renal (pro)renin receptor upregulation in diabetic rats through enhanced angiotensin AT1 receptor and NADPH oxidase activity.
- Local renal aldosterone production induces inflammation and matrix formation in kidneys of diabetic rats.
- ADVANCE in management of vascular complications of diabetes.
- Renal nitric oxide production is decreased in diabetic rats and improved by AT1 receptor blockade.
- Endothelium-derived relaxing factor modulates renal interstitial cyclic GMP.
- Nitric oxide alters renal function and guanosine 3',5'-cyclic monophosphate.
- Intrarenal DA2 dopamine receptor stimulation in the conscious dog.
- Design of potent substrate-analogue inhibitors of canine renin.
- Dopamine-1 and dopamine-2 mechanisms in the control of renal function.
- Evidence that dopamine-2 mechanisms control renal function.
- Physiological modulation of renal function by the renal dopaminergic system.
- Combined intrarenal blockade of the renin-angiotensin system in the conscious dog.
- Evidence that intrarenal dopamine acts as a paracrine substance at the renal tubule.
- Combined intrarenal renin-angiotensin blockade alters renal function and this is reversed by angiotensin II.
- Angiotensin II modulates the intrarenal effects of atrial natriuretic peptide.
- Intrarenal dopamine-1 receptors control renal function.
- Intrarenal renin inhibition increases renal function by an angiotensin II-dependent mechanism.
- Intrarenal dopamine acts at the dopamine-1 receptor to control renal function.
- Intrarenal effects of [Ala-Pro-Gly-(Ile3-Val5)] angiotensin II in the conscious dog.
- Renal sensitivity to angiotensin II in the conscious dog.
- The effect of vasopressin in water-loaded hypokalemic patients is prostaglandin-independent.
- Polymerase chain reaction versus Southern blot hybridization. Detection of immunoglobulin heavy-chain gene rearrangements.
- Renal interstitial fluid angiotensin. Modulation by anesthesia, epinephrine, sodium depletion, and renin inhibition.
- Increased disorderliness and amplified basal and pulsatile aldosterone secretion in patients with primary aldosteronism.
- Rat renal interstitial bradykinin, prostaglandin E2, and cyclic guanosine 3',5'-monophosphate. Effects of altered sodium intake.
- Evidence that intrarenal bradykinin plays a role in regulation of renal function.
- High Glucose Induces Podocyte Injury via Enhanced (Pro)renin Receptor-Wnt-β-Catenin-Snail Signaling Pathway.
- Stimulation of renal interstitial bradykinin by sodium depletion.
- Significant hyponatremia following DDAVP administration in a healthy adult.
- The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3', 5'-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats.
- Sodium intake markedly alters renal interstitial fluid adenosine.
- Renin-angiotensin system modulates renal bradykinin production.
- Preferential release of renal dopamine into the tubule lumen: effect of chronic sodium loading.
- Intrarenal dopamine production and distribution in the rat. Physiological control of sodium excretion.
- Bradykinin B2 receptor modulates renal prostaglandin E2 and nitric oxide.
- The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats.
- The subtype 2 angiotensin receptor regulates renal prostaglandin F2 alpha formation in conscious rats.
- Renal dopamine production and release in the rat: a microdialysis study.
- Expression of the subtype 2 angiotensin (AT2) receptor protein in rat kidney.
- Immunolocalization of subtype 2 angiotensin II (AT2) receptor protein in rat heart.
- Regulation of jejunal sodium and water absorption by angiotensin subtype receptors.
- Compartmentalization of extracellular cGMP determines absorptive or secretory responses in the rat jejunum.
- Action of angiotensin receptor subtypes on the renal tubules and vasculature: implications for volume homeostasis and atherosclerosis.
- Differential regulation of renal angiotensin subtype AT1A and AT2 receptor protein in rats with angiotensin-dependent hypertension.
- Protective role of the angiotensin AT2 receptor in a renal wrap hypertension model.
Schools
Tanta University Faculty Of Medicine
University Tex Med Branch
University Tex Health Science Center
University Of Virginia
Doctors Specialties
- Endocrinology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
Education
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University of Virginia -
University of Texas Medical Branch Hospitals -
Tanta University Faculty of Medicine
Drug Facts
| NPI NUMBER | 1316082290 | |
| NPPES Provider LastName | SIRAGY | |
| NPPES Provider FirstName | HELMY | |
| NPPES Provider ZIPCode | 22903 | |
| NPPES Provider State | VA | |
| Specialty Description | Endocrinology | |
| Total Claim Count | 24.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1316082290 |
| Last Name Of The Provider | SIRAGY |
| First Name Of The Provider | HELMY |
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