Professor, Vice Chair for Research, Department of Pediatrics, Baylor College of Medicine
Allergy & Immunology
Dr. Jordan S. Orange, MD
|
|
Give Review
Jordan Orange is an expert in the field of Allergy & Immunology. He graduated from Warren Alpert Medical School of Brown University. He has 4 awards "America's Top Doctors", "Top Doctors:SE Texas", "Philadelphia Magazine" and "Fellow (FAAAAI)". Doctor Jordan S. Orange, MD has written publications. He has 100 publications published with PubMed. The lastest publication is: 'Adoptive immunotherapy for primary immunodeficiency disorders with virus-specific T lymphocytes.'
Publications
- Recurrent Muscle Weakness with Rhabdomyolysis, Metabolic Crises, and Cardiac Arrhythmia Due to Bi-allelic TANGO2 Mutations.
- Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease.
- Adoptive immunotherapy for primary immunodeficiency disorders with virus-specific T lymphocytes.
- The Use of Interquartile Deviation in Establishing Delphi Panel Consensus: A Prioritization of Intravenous Immunoglobulin Utilization.
- Insights into primary immune deficiency from quantitative microscopy.
- Primary Immunodeficiency Diseases: An Opportunity in Pediatrics for Improving Patient Outcomes.
- Molecular mechanisms of functional natural killer deficiency in patients with partial DiGeorge syndrome.
- PTEN is a negative regulator of NK cell cytolytic function.
- Vaccine-associated varicella and rubella infections in severe combined immunodeficiency with isolated CD4 lymphocytopenia and mutations in IL7R detected by tandem whol...
- Food allergy in patients with primary immunodeficiency diseases: Prevalence within the US Immunodeficiency Network (USIDNET).
- Compound Heterozygous CORO1A Mutations in Siblings with a Mucocutaneous-Immunodeficiency Syndrome of Epidermodysplasia Verruciformis-HPV, Molluscum Contagiosum and Gra...
- Evaluation of prolonged fatigue post-west nile virus infection and association of fatigue with elevated antiviral and proinflammatory cytokines.
- Severe cutaneous human papillomavirus infection associated with natural killer cell deficiency following stem cell transplantation for severe combined immunodeficiency.
- Burden of copy number variation in common variable immunodeficiency.
- Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation.
- PGM3 Mutations Cause a Congenital Disorder of Glycosylation with Severe Immunodeficiency and Skeletal Dysplasia.
- Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A.
- Global overview of primary immunodeficiencies: a report from Jeffrey Modell Centers worldwide focused on diagnosis, treatment, and discovery.
- Cell biological steps and checkpoints in accessing NK cell cytotoxicity.
- Modeling Primary Immunodeficiency Disease Epidemiology and Its Treatment to Estimate Latent Therapeutic Demand for Immunoglobulin.
- GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics and immunity.
- Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.
- Natural killer cell deficiency.
- Prioritization of evidence-based indications for intravenous immunoglobulin.
- Immunologic features of cornelia de lange syndrome.
- Differential Localization of T-bet and Eomes in CD8 T Cell Memory Populations.
- Bioavailability of IgG Administered by the Subcutaneous Route.
- Rapid activation receptor- or IL-2-induced lytic granule convergence in human natural killer cells requires Src, but not downstream signaling.
- Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.
- Immunodeficiency in patients with 49,XXXXY chromosomal variation.
- Severe Combined Immunodeficiency Resulting From Mutations in MTHFD1.
- Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency.
- The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation.
- New views of the human NK cell immunological synapse: recent advances enabled by super- and high-resolution imaging techniques.
- Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56bright subset.
- CD2 Promotes Human Natural Killer Cell Membrane Nanotube Formation.
- NK cell lytic granules are highly motile at the immunological synapse and require F-actin for post-degranulation persistence.
- Comparison of American and European practices in the management of patients with primary immunodeficiencies.
- Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation.
- CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia.
- Multiple distinct NK-cell synapses.
- Phosphorylation of the myosin IIA tailpiece regulates single myosin IIA molecule association with lytic granules to promote NK-cell cytotoxicity.
- Global study of primary immunodeficiency diseases (PI)-diagnosis, treatment, and economic impact: an updated report from the Jeffrey Modell Foundation.
- Autoimmune regulator (AIRE) contributes to Dectin-1-induced TNF-? production and complexes with caspase recruitment domain-containing protein 9 (CARD9), spleen tyrosin...
- Natural Killer Cell Lytic Granule Secretion Occurs through a Pervasive Actin Network at the Immune Synapse.
- Novel inborn error of folate metabolism: identification by exome capture and sequencing of mutations in the MTHFD1 gene in a single proband.
- Congenital alterations of NEMO glutamic acid 223 result in hypohidrotic ectodermal dysplasia and immunodeficiency with normal serum IgG levels.
- Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome.
- Eosinophilic fasciitis mimicking angioedema and treatment response to infliximab in a pediatric patient.
- Genome-wide association identifies diverse causes of common variable immunodeficiency.
- IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.
- Invariant natural killer T cells from children with versus without food allergy exhibit differential responsiveness to milk-derived sphingomyelin.
- The autoimmune regulator (AIRE), which is defective in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients, is expressed in human epidermal and fol...
- Substance P inhibits natural killer cell cytotoxicity through the neurokinin-1 receptor.
- Complications of tumor necrosis factor-α blockade in chronic granulomatous disease-related colitis.
- Stem-cell gene therapy for the Wiskott-Aldrich syndrome.
- Impact of trough IgG on pneumonia incidence in primary immunodeficiency: A meta-analysis of clinical studies.
- A custom 148 gene-based resequencing chip and the SNP explorer software: new tools to study antibody deficiency.
- Cutting edge: association with I kappa B kinase beta regulates the subcellular localization of Homer3.
- miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta.
- Rapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment.
- Latent herpesviruses: aligning human and murine NK cells.
- Use of intravenous immunoglobulin and adjunctive therapies in the treatment of primary immunodeficiencies: A working group report of and study by the Primary Immunodef...
- Use of cytokine therapy in primary immunodeficiency.
- Analysis of the NK cell immunological synapse.
- Therapeutic use of immunoglobulins.
- Chipping away at gamma-H2AX foci.
- Comèl-Netherton syndrome defined as primary immunodeficiency.
- Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse.
- Immune dysregulation in severe influenza.
- Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors.
- Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activ...
- Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficie...
- Hypomorphic nuclear factor-kappaB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity.
- Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases.
- Immunodeficiency disorders. Preface.
- IKBKG (nuclear factor-kappa B essential modulator) mutation can be associated with opportunistic infection without impairing Toll-like receptor function.
- Evaluation and clinical interpretation of hypergammaglobulinemia E: differentiating atopy from immunodeficiency.
- Lymphotoxin-alpha 1 beta 2 and LIGHT induce classical and noncanonical NF-kappa B-dependent proinflammatory gene expression in vascular endothelial cells.
- 1. Lymphocytes.
- NKp30 ligation induces rapid activation of the canonical NF-kappaB pathway in NK cells.
- Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse.
- Myosin IIA is required for cytolytic granule exocytosis in human NK cells.
- Hypogammaglobulinemia in a pediatric tertiary care setting.
- Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta.
- Asymmetric T lymphocyte division in the initiation of adaptive immune responses.
- Superantigen presentation by airway smooth muscle to CD4+ T lymphocytes elicits reciprocal proasthmatic changes in airway function.
- Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection.
- The lytic NK cell immunological synapse and sequential steps in its formation.
- Human natural killer cell deficiencies.
- Impaired specific antibody response and increased B-cell population in transient hypogammaglobulinemia of infancy.
- Formation of a WIP-, WASp-, actin-, and myosin IIA-containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signaling.
- Natural killer cells in human health and disease.
- Development of a clinical assay to evaluate toll-like receptor function.
- Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin.
- Congenital immunodeficiencies and sepsis.
- Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation.
- Natural killer cells inhibit hepatitis C virus expression.
- Characteristics of mycobacterial infection in patients with immunodeficiency and nuclear factor-kappaB essential modulator mutation, with or without ectodermal dysplasia.
Schools
Brown University Alpert Medical School
Chldns Hospital Philadelphia
Boston Chldns Hospital
Doctors Specialties
- Pediatrics
- Allergy
- Immunology
Accepted Insurances
Awards
- America's Top Doctors
- Top Doctors:SE Texas
- Philadelphia Magazine
- Fellow (FAAAAI)
Education
-
Boston Children's Hospital -
Children's Hospital of Philadelphia -
Warren Alpert Medical School of Brown University
Hospital
-
Texas Children's Hospital
Helpful Reviews
Similar Doctors
|
|
Dr. Drew Weissman, MD
 This Doctor is OpenDoctor Recommended.
|
|
|
Nancy D. Gordon, LCSW
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. John R. Cohn, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Pierre L. Yong, MD
This Doctor is OpenDoctor Recommended.
|
|
Dr. Manav Segal, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Caitlin W. Elgarten, MD |
|
|
Dr. Fanny M. Murken, MD |
|
|
Dr. Jonathan M. Spergel, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Shruti A. Fadia, MD |
|
|
Dr. Andrew S. Wood, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Rushani W. Saltzman, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Susmita Pati, MD |
|
|
Dr. Tamara P. Miller, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Melkorka S. Maggadottir, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Usha M. Childs, MD |
|
|
Dr. Sharon M. Elvey, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Matthew I. Fogg, MD
This Doctor is OpenDoctor Recommended.
|