Professor, Neurology, UCSF School of Medicine
Neurology
Dr. Lennart Mucke, MD
Lennart Mucke practices Neurology. Lennart Mucke, MD is a published doctor as well. He has 101 publications published. The latest was: Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females.
Publications
- Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice.
- Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.
- Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice.
- Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.
- Tau reduction prevents disease in a mouse model of Dravet syndrome.
- Life Extension Factor Klotho Enhances Cognition.
- Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease.
- Physiologic Brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-?
- Age-appropriate cognition and subtle dopamine-independent motor deficits in aged Tau knockout mice.
- Human P301L-Mutant Tau Expression in Mouse Entorhinal-Hippocampal Network Causes Tau Aggregation and Presynaptic Pathology but No Cognitive Deficits.
- Neurotoxicity of Amyloid β-Protein: Synaptic and Network Dysfunction.
- Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model.
- Alzheimer mechanisms and therapeutic strategies.
- Tau reduction diminishes spatial learning and memory deficits after mild repetitive traumatic Brain injury in mice.
- Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease.
- Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein tra...
- The many faces of tau.
- Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.
- Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.
- Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network.
- Quantifying biomarkers of cognitive dysfunction and neuronal network hyperexcitability in mouse models of Alzheimer's disease: depletion of calcium-dependent proteins ...
- Tau reduction prevents Abeta-induced defects in axonal transport.
- Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice.
- Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks.
- Phospholipase A2 and arachidonic acid in Alzheimer''s disease.
- Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein.
- Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease.
- Synaptic depression and aberrant excitatory network activity in Alzheimer's disease: two faces of the same coin?
- Neuroscience: Alzheimer''s disease.
- A roadmap for the prevention of Dementia II: Leon Thal Symposium 2008.
- Alzheimer''s disease: A prion protein connection.
- Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein...
- Epilepsy and cognitive impairments in Alzheimer disease.
- Collagen VI protects neurons against Abeta toxicity.
- Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease.
- Genes contributing to prion pathogenesis.
- Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease.
- Paths of convergence: sirtuins in aging and neurodegeneration.
- Abnormal social behaviors in mice lacking Fgf17.
- Spatial cognition and the human navigation network in AD and MCI.
- Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.
- Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.
- Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.
- Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease.
- Altered navigational strategy use and visuospatial deficits in hAPP transgenic mice.
- 100 years and counting: prospects for defeating Alzheimer's disease.
- Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology.
- A network dysfunction perspective on neurodegenerative diseases.
- Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.
- PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice.
- Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor...
- Alzheimer''s disease: A needle from the haystack.
- Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.
- Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic mice.
- SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
- High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease.
- Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other...
- Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation.
- RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice.
- Food for thought: essential fatty acid protects against neuronal deficits in transgenic mouse model of AD.
- Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease.
- Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice.
- Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in Brains of transgenic mice.
- Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.
- Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits.
- Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid be...
- Inflammation in neurodegenerative disease--a double-edged sword.
- Androgens protect against apolipoprotein E4-induced cognitive deficits.
- beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease.
- TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.
- Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice.
- Ibuprofen, inflammation and Alzheimer disease.
- Alzheimer's disease-like cerebrovascular pathology in transforming growth factor-beta 1 transgenic mice and functional metabolic correlates.
- High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation.
- Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease.
- Apolipoprotein E and cognitive performance.
- Hypothalamic-pituitary-adrenal dysfunction in Apoe(-/-) mice: possible role in behavioral and metabolic alterations.
- Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders.
- Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice.
- Age-related behavioural deficits in transgenic mice expressing the HIV-1 coat protein gp120.
- Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precurs...
- Genetically-targeted and conditionally-regulated ablation of astroglial cells in the central, enteric and peripheral nervous systems in adult transgenic mice.
- Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice.
- Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis.
- Expression of human apolipoprotein E3 or E4 in the Brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.
- Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models.
- Isoform-specific effects of human apolipoprotein E on Brain function revealed in ApoE knockout mice: increased susceptibility of females.
- Amyloid protein precursor stimulates excitatory amino acid transport. Implications for roles in neuroprotection and pathogenesis.
- Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice.
- Novel role of human CD4 molecule identified in neurodegeneration.
- Transgenic mice with Cerebral expression of human immunodeficiency virus type-1 coat protein gp120 show divergent changes in short- and long-term potentiation in CA1 h...
- Dynamic regulation of c-Jun N-terminal kinase activity in mouse Brain by environmental stimuli.
- Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer''s disease.
- Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie.
- Astroglial overproduction of TGF-beta 1 enhances inflammatory central nervous system disease in transgenic mice .
- Corticotropin-releasing factor and adrenocorticotrophic hormone as potential central mediators of OB effects.
- Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo.
- Cellular signaling roles of TGF beta, TNF alpha and beta APP in Brain injury responses and Alzheimer''s disease.
- Spatial learning deficit in mice expressing human 751-amino acid beta-amyloid precursor protein.
- Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase.
Schools
University of Medicine G246ttingen
Cleveland Clinic
Massachusetts General Hospital
Conditions Treated
- Brain Aneurysm
- Cerebral Artery Thrombosis
- Cerebral Hemorrhage
- Dementia
- View All
Doctors Specialties
- Neurology
Accepted Insurances
Education
-
Massachusetts General Hospital -
Cleveland Clinic Foundation -
Freie University Berlin Faculty of Medicine
Hospital
-
UCSF Medical Center
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