Professor, Pediatrics, Vanderbilt University School of Medicine

Pediatric Infectious Disease

Dr. Mark R. Denison, MD

Mark Denison works in the field of Pediatric Infectious Disease. He attended University of Kansas School of Medicine. He over the years received 1 awards: "Fellow". Mark Denison has written publications. He has 34 publications published with PubMed. The lastest paper is: 'Mutations across murine hepatitis virus nsp4 alter virus fitness and membrane modifications.'

Publications

Mutations across murine hepatitis virus nsp4 alter virus fitness and membrane modifications.
Evaluation of Serologic and Antigenic Relationships Between Middle Eastern Respiratory Syndrome Coronavirus and Other Coronaviruses to Develop Vaccine Platforms for th...
Coronaviruses as DNA wannabes: a new model for the regulation of RNA virus replication fidelity.
Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activity.
Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics.
Murine hepatitis virus nsp4 N258T mutants are not temperature-sensitive.
A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease.
Implications of altered replication fidelity on the evolution and pathogenesis of coronaviruses.
Temperature-sensitive mutants and revertants in the coronavirus nonstructural protein 5 protease (3CLpro) define residues involved in long-distance communication and r...
Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity.
Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.
ANDES: Statistical tools for the ANalyses of DEep Sequencing.
Exchange of the coronavirus replicase polyprotein cleavage sites alters protease specificity and processing.
Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing.
Use of intravenous zanamivir after development of oseltamivir resistance in a critically Ill immunosuppressed child infected with 2009 pandemic influenza A (H1N1) virus.
Murine hepatitis virus nonstructural protein 4 regulates virus-induced membrane modifications and replication complex function.
Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice.
Murine coronaviruses encoding nsp2 at different genomic loci have altered replication, protein expression, and localization.
Seeking membranes: positive-strand RNA virus replication complexes.
A novel mutation in murine hepatitis virus nsp5, the viral 3C-like proteinase, causes temperature-sensitive defects in viral growth and protein processing.
SARS coronavirus replicase proteins in pathogenesis.
High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants.
Genetic analysis of Murine hepatitis virus nsp4 in virus replication.
Coronavirus replication does not require the autophagy gene ATG5.
Processing of open reading frame 1a replicase proteins nsp7 to nsp10 in murine hepatitis virus strain A59 replication.
Murine hepatitis virus replicase protein nsp10 is a critical regulator of viral RNA synthesis.
Replication of murine hepatitis virus is regulated by papain-like proteinase 1 processing of nonstructural proteins 1, 2, and 3.
Effects of mutagenesis of murine hepatitis virus nsp1 and nsp14 on replication in culture.
The nsp2 proteins of mouse hepatitis virus and SARS coronavirus are dispensable for viral replication.
MHV-A59 ORF1a replicase protein nsp7-nsp10 processing in replication.
Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice.
The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication.
Severe acute respiratory syndrome coronavirus pathogenesis, disease and vaccines: an update.

Schools

University of Kansas School of Medicine
University Ia Hospital

Doctors Specialties

Pediatric Infectious Disease Medicine
Pediatric Infectious Disease

Accepted Insurances

Awards

Fellow

Education

University of Iowa Hospitals and Clinics
University of Kansas School of Medicine

Hospital

Vanderbilt Hospital and Clinics

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