Professor, Pediatrics, University of Texas Southwestern Medical Center, Southwestern Medical School
Neonat/Perinatology
Dr. Philip W. Shaul, MD
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Philip Shaul works in the field of Neonat/Perinatology. He went to University Hospital - University of Cincinnati College of Medicine. He over the years received 1 awards: "Elected Member". Dr. Philip W. Shaul is a published doctor and has 99 publications published. The lastest was: 'Nitric oxide synthase isoform expression in the developing lung epithelium.'
Publications
- ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice.
- Fcγ receptors and ligands and cardiovascular disease.
- IgG Receptor FcγRIIB Plays a Key Role in Obesity-Induced Hypertension.
- HDL Cholesterol Efflux Capacity and Incident Cardiovascular Events.
- Bazedoxifene and Conjugated Estrogen Prevent Diet-induced Obesity, Hepatic Steatosis and Type 2 Diabetes in Mice Without Impacting the Reproductive Tract.
- The Cholesterol Metabolite 27-Hydroxycholesterol Promotes Atherosclerosis via Proinflammatory Processes Mediated by Estrogen Receptor Alpha.
- Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions.
- Recent insights into non-nuclear actions of estrogen receptor alpha.
- 27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth.
- Regulation of Signal Transduction by HDL.
- C-reactive protein causes insulin resistance in mice through Fcγ receptor IIB-mediated inhibition of skeletal muscle glucose delivery.
- Non-Nuclear-Initiated Actions of the Estrogen Receptor Protect Cortical Bone Mass.
- Point Mutations in the ERα Gαi Binding Domain Segregate Nonnuclear from Nuclear Receptor Function.
- Scavenger Receptor Class B Type I (SR-BI) is a Plasma Membrane Cholesterol Sensor.
- Novel biological functions of high-density lipoprotein cholesterol.
- Functions of scavenger receptor class B, type I in atherosclerosis.
- New Insights into the Molecular Basis of the Antiphospholipid Syndrome.
- Coupling of fc? receptor I to fc? receptor IIb by SRC kinase mediates C-reactive protein impairment of endothelial function.
- PON-dering differences in HDL function in coronary artery disease.
- Inhaled nitric oxide and bronchopulmonary dysplasia.
- Regulation of VEGF Induced Endothelial Cell Migration by Mitochondrial Reactive Oxygen Species.
- Non-nuclear Estrogen Receptor Signaling in the Endothelium.
- 27-Hydroxycholesterol: the first identified endogenous SERM.
- Patent ductus arteriosus ligation alters pulmonary gene expression in preterm baboons.
- The effects of postnatal estrogen therapy on brain development in preterm baboons.
- Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2.
- Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice.
- Signaling by the high-affinity HDL receptor scavenger receptor B type I.
- C-reactive protein inhibits insulin activation of endothelial nitric oxide synthase via the immunoreceptor tyrosine-based inhibition motif of FcgammaRIIB and SHIP-1.
- Postnatal estradiol up-regulates lung nitric oxide synthases and improves lung function in bronchopulmonary dysplasia.
- The scavenger receptor class B type I adaptor protein PDZK1 maintains endothelial monolayer integrity.
- 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator.
- 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen.
- Biochemical consequences of the NOS3 Glu298Asp variation in human endothelium: altered caveolar localization and impaired response to shear.
- Endothelin-1 induces alveolar epithelial-mesenchymal transition through endothelin type A receptor-mediated production of TGF-beta1.
- Nitric oxide attenuates epithelial-mesenchymal transition in alveolar epithelial cells.
- Role of high-density lipoprotein and scavenger receptor B type I in the promotion of endothelial repair.
- Direct Interactions with G alpha i and G betagamma mediate nongenomic signaling by estrogen receptor alpha.
- C-reactive protein downregulates endothelial NO synthase and attenuates reendothelialization in vivo in mice.
- Inhaled nitric oxide: effects on cerebral growth and injury in a baboon model of premature delivery.
- The cold, hard truth about pediatric research.
- C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice.
- Endothelial and antithrombotic actions of HDL.
- High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I.
- Surfactant composition and function in a primate model of infant chronic lung disease: effects of inhaled nitric oxide.
- Effect of ductus ligation on cardiopulmonary function in premature baboons.
- Pulmonary and systemic nitric oxide metabolites in a baboon model of neonatal chronic lung disease.
- FcgammaRIIB mediates C-reactive protein inhibition of endothelial NO synthase.
- Caveolin-1 is not required for murine intestinal cholesterol transport.
- Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor-BI mediate HDL-initiated signaling.
- Molecular basis of estrogen-induced cyclooxygenase type 1 upregulation in endothelial cells.
- Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease.
- Dissecting the basis of nongenomic activation of endothelial nitric oxide synthase by estradiol: role of ERalpha domains with known nuclear functions.
- HDL action on the vascular wall: is the answer NO?
- Hypoxia-induced left ventricular dysfunction in myoglobin-deficient mice.
- HDL stimulation of endothelial nitric oxide synthase: a novel mechanism of HDL action.
- Pulmonary NO synthase expression is attenuated in a fetal baboon model of chronic lung disease.
- Vasomodulation by skeletal muscle-derived nitric oxide requires alpha-syntrophin-mediated sarcolemmal localization of neuronal Nitric oxide synthase.
- High density lipoprotein-induced endothelial nitric-oxide synthase activation is mediated by Akt and MAP kinases.
- Developmental changes in nitric oxide synthase isoform expression and nitric oxide production in fetal baboon lung.
- Estrogen causes dynamic alterations in endothelial estrogen receptor expression.
- Estrogen modulation of endothelial nitric oxide synthase.
- Conventional estrogen receptors are found in the plasma membrane of vaginal epithelial cells of the rat.
- Rapid activation of endothelial NO synthase by estrogen: evidence for a steroid receptor fast-action complex (SRFC) in caveolae.
- Estrogen acutely activates prostacyclin synthesis in ovine fetal pulmonary artery endothelium.
- ERbeta has nongenomic action in caveolae.
- Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta.
- Regulation of endothelial nitric oxide synthase: location, location, location.
- Antiphospholipid antibodies attenuate endothelial repair and promote neointima formation in mice.
- Neurologic and developmental status related to the evolution of visual-motor abnormalities from birth to 2 years of age in preterm infants with intraventricular hemorr...
- Decreased amniotic fluid magnesium concentration in diabetic pregnancy.
- Modulation of endothelial NO production by high-density lipoprotein.
- Effects of chronic estrogen-receptor blockade on ovine perinatal pulmonary circulation.
- High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase.
- Maternal vitamin A administration and the fetal ductus arteriosus.
- Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Galpha(i).
- Estrogen receptor alpha and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae.
- Sustained endothelial nitric-oxide synthase activation requires capacitative Ca2+ entry.
- Regulation of types I and III NOS in ovine uterine arteries by daily and acute estrogen exposure.
- High density lipoprotein prevents oxidized low density lipoprotein-induced inhibition of endothelial nitric-oxide synthase localization and activation in caveolae.
- Molecular basis of cell-specific endothelial nitric-oxide synthase expression in airway epithelium.
- Novel role of estrogen receptors in vascular endothelium.
- Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2.
- Cell growth modulates nitric oxide synthase expression in fetal pulmonary artery endothelial cells.
- Oxidized low density lipoprotein displaces endothelial nitric-oxide synthase (eNOS) from plasmalemmal caveolae and impairs eNOS activation.
- Nitric oxide (NO) upregulates NO synthase expression in fetal intrapulmonary artery endothelial cells.
- Establishment of an immortalized fetal intrapulmonary artery endothelial cell line.
- Rapid activation of endothelial nitric oxide synthase by estrogen.
- Regulation of vasodilator synthesis during lung development.
- Estrogen acutely stimulates endothelial nitric oxide synthase in H441 human airway epithelial cells.
- Nitric oxide synthase isoform expression in the developing lung epithelium.
- Glucocorticoids downregulate cyclooxygenase-1 gene expression and prostacyclin synthesis in fetal pulmonary artery endothelium.
- Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen.
- Developmental changes in prostacyclin synthesis are conserved in cultured pulmonary endothelium and vascular smooth muscle.
- Role of plasmalemmal caveolae in signal transduction.
- Estrogen upregulates cyclooxygenase-1 gene expression in ovine fetal pulmonary artery endothelium.
- Ontogeny of cyclooxygenase-1 and cyclooxygenase-2 gene expression in ovine lung.
- Ontogeny of nitric oxide in the pulmonary vasculature.
Schools
University of Cincinnati Main Campus
Chldns Hospital Med Center
Womens Infants Hospital Ri
Doctors Specialties
- Neonatal Medicine
- Neonat/Perinatology
Accepted Insurances
Awards
- Elected Member
Education
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University Hospital - University of Cincinnati College of Medicine -
Cincinnati Children's Hospital Medical Center -
University of Cincinnati College of Medicine
Hospital
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University of Texas Southwestern Medical Center -
Children's Health System of Texas
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