Professor, Medicine, Vanderbilt University School of Medicine
Nephrology
Dr. Roy Zent, MD
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Dr. Roy Zent practices Nephrology. Zent is also a published doctor. He has 101 paper published. The most recent paper is: ROS stimulate reorganization of mesangial cell-collagen gels by tyrosine kinase signaling.
Publications
- Extracellular rigidity sensing by talin isoform-specific mechanical linkages.
- Cdc42 regulates epithelial cell polarity and cytoskeletal function in Kidney tubule development.
- Integrin α3β1 regulates Kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt.
- Hypertension Is a Major Contributor to 20-Hydroxyeicosatetraenoic Acid-Mediated Kidney Injury in Diabetic Nephropathy.
- Renal fibrosis is not reduced by blocking transforming growth factor-β signaling in matrix-producing interstitial cells.
- p47(phox) contributes to albuminuria and Kidney fibrosis in mice.
- Arrestins regulate cell spreading and motility via focal adhesion dynamics.
- Epithelial β1 integrin is required for lung branching morphogenesis and alveolarization.
- Effects of High Glucose on Integrin Activity and Fibronectin Matrix Assembly by Mesangial Cells.
- PPARα activation can help prevent and treat non-small cell lung cancer.
- Integrins in Kidney disease.
- Extracellular loop II modulates GTP sensitivity of the prostaglandin EP3 receptor.
- EP1 disruption attenuates end-organ damage in a mouse model of Hypertension.
- Nonmuscle myosin II regulation of lung epithelial morphology.
- Connecting the Segments.
- CD98 Increases Renal Epithelial Cell Proliferation by Activating MAPKs.
- How Does TGF-β Mediate Tubulointerstitial Fibrosis?
- Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity.
- TGF-beta receptor deletion in the Renal collecting system exacerbates fibrosis.
- TRAIL and interferon-alpha act synergistically to induce Renal cell carcinoma apoptosis.
- MT1-MMP-mediated basement membrane remodeling modulates Renal development.
- Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development.
- Regulation of endothelial cell functions by basement membrane- and arachidonic acid-derived products.
- Integrin {alpha}1{beta}1 promotes caveolin-1 dephosphorylation by activating T cell protein-tyrosine phosphatase.
- TGF-? sequestration by mesangial cell integrin ?v?8: A novel mechanism of glomerular endothelial cell regulation.
- Membrane-type 4 matrix metalloproteinase (MT4-MMP) modulates water homeostasis in mice.
- Extracellular matrix receptors in branched organs.
- Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130).
- Renal collecting system growth and function depend upon embryonic γ1 laminin expression.
- Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis.
- ?-Catenin and K-RAS Synergize to Form Primitive Renal Epithelial Tumors with Features of Epithelial Wilms' Tumors.
- Hold tight or you'll fall off: CD151 helps podocytes stick in high-pressure situations.
- New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.
- Prostaglandin E2-EP4 receptor promotes endothelial cell migration via ERK activation and angiogenesis in vivo.
- Angiogenesis in diabetic Nephropathy.
- Signaling pathways regulating TC21-induced tumorigenesis.
- ErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine Kidney cell tubulogenesis.
- NPXY motifs in the beta1 integrin cytoplasmic tail are required for functional reovirus entry.
- Mouse EP3 alpha, beta, and gamma receptor variants reduce tumor cell proliferation and tumorigenesis in vivo.
- Human podocytes adhere to the KRGDS motif of the alpha3alpha4alpha5 collagen IV network.
- Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity.
- Integrins, extracellular matrix, and terminal differentiation of Renal epithelial cells.
- Kindlin-2 controls bidirectional signaling of integrins.
- Apoptosis of the thick ascending limb results in Acute kidney injury.
- Functional analysis of the cytoplasmic domain of the integrin {alpha}1 subunit in endothelial cells.
- Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer.
- Transforming growth factor-beta (TGF-beta) and TGF-beta-associated kinase 1 are required for R-Ras-mediated transformation of mammary epithelial cells.
- Cross-talk between integrins alpha1beta1 and alpha2beta1 in Renal epithelial cells.
- Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton.
- Regulation of matrix synthesis, remodeling and accumulation in glomerulosclerosis.
- The tail of integrins, talin, and kindlins.
- Modification of collagen IV by glucose or methylglyoxal alters distinct mesangial cell functions.
- Distinct roles for basal and induced COX-2 in podocyte injury.
- beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity.
- The role of integrin alpha8beta1 in fetal lung morphogenesis and injury.
- Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity.
- Integrin-linked kinase is an adaptor With essential functions during mouse development.
- ZO-1 and ZONAB interact to regulate proximal tubular cell differentiation.
- Sirt1 activation protects the mouse Renal medulla from oxidative injury.
- The role of a recombinant fragment of laminin-332 in integrin alpha3beta1-dependent cell binding, spreading and migration.
- Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 express...
- Expression and molecular pharmacology of the mouse CRTH2 receptor.
- Integrins: sensors of extracellular matrix and modulators of cell function.
- Alpha(v)beta3 and alpha(v)beta5 integrins bind both the proximal RGD site and non-RGD motifs Within noncollagenous (NC1) domain of the alpha3 chain of type IV collagen...
- Proteolytic processing of laminin-5 by MT1-MMP in tissues and its effects on epithelial cell morphology.
- Membrane-associated HB-EGF modulates HGF-induced cellular Responses in MDCK cells.
- Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis.
- Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury.
- A woman with Chronic hepatitis C infection and nephrotic syndrome who developed multiple renal lesions after interferon alfa therapy.
- CD98hc (SLC3A2) interaction With beta 1 integrins is required for transformation.
- Integrin-dependent PLC-gamma1 phosphorylation mediates fibronectin-dependent adhesion.
- CD98 modulates integrin beta1 function in polarized epithelial cells.
- Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells.
- Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids.
- Inhibition of Pkhd1 impairs tubulomorphogenesis of cultured IMCD cells.
- An orthotopic model of lung cancer to analyze primary and metastatic NSCLC growth in integrin alpha1-null mice.
- Role of integrin alpha1beta1 in the regulation of Renal medullary osmolyte concentration.
- Production and characterization of mouse ureteric bud cell-specific rat hybridoma antibodies utilizing subtractive immunization and high-throughput screening.
- Antiangiogenic therapy in diabetic Nephropathy.
- H-Ras, R-Ras, and TC21 differentially regulate ureteric bud cell branching morphogenesis.
- Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and Kidney epithelial sodium channel.
- Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3.
- Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth.
- PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis.
- Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation.
- Chronic myeloid leukemia-associated membranoproliferative glomerulonephritis that responded to imatinib mesylate therapy.
- Glomerular injury is exacerbated in diabetic integrin alpha1-null mice.
- Hearing thresholds in CAPD patients.
- Puromycin aminonucleoside inhibits mesangial cell-induced contraction of collagen gels by stimulating production of reactive oxygen species.
- IgG heavy-chain deposition Disease.
- Crescentic nephritis at Groote Schuur Hospital, South Africa--not a benign Disease.
- Diagnosis of lymphoma in a continuous ambulatory peritoneal dialysis patient by peritoneal fluid cytology.
- Continuous ambulatory peritoneal dialysis: an option in the developing world?
- A flight of fantasy: false memories in frontal lobe Disease.
- Idiopathic membranous Nephropathy in the elderly: a comparative study.
- Thrombotic microangiopathy in Renal transplant recipients treated with cyclosporin A.
- Tyrosine kinase cell signaling pathways of rat mesangial cells in 3-dimensional cultures: Response to fetal bovine serum and platelet-derived growth factor-BB.
- ROS stimulate reorganization of mesangial cell-collagen gels by tyrosine kinase signaling.
- The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation.
- Class- and splice variant-specific association of CD98 With integrin beta cytoplasmic domains.
Procedures Preformed
- Hemodialysis
- Peritoneal Dialysis
Conditions Treated
- Acidosis
- Acute Kidney Failure
- Calcium Metabolism Disorders
- Chronic Glomerulonephritis
- View All
Doctors Specialties
- Nephrology
Accepted Insurances
Education
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University of the Witwatersrand
Hospital
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Vanderbilt Hospital and Clinics
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