Professor, Pathology, University of Virginia School of Medicine
Allergy & Immunology
Dr. Thomas J. Braciale, MD
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Doctor Thomas J. Braciale, MD is an expert in the field of Allergy & Immunology. Doctor Thomas J. Braciale, MD is also published. He has 100 publications published. The lastest publication: "A helper factor needed for the generation of mouse cytolytic T lymphocytes is made by tumor cell lines, cloned T cells, and spleen cells exposed to a variety of stimuli.'
Publications
- Liver-Resident CD103+ Dendritic Cells Prime Antiviral CD8+ T Cells In Situ.
- Control of pathogenic effector T-cell activities in situ by PD-L1 expression on respiratory inflammatory dendritic cells during respiratory syncytial virus infection.
- Late Engagement of CD86 after Influenza Virus Clearance Promotes Recovery in a FoxP3+ Regulatory T Cell Dependent Manner.
- Influenza pathogenesis: Club cells take the "cure".
- The Effector T Cell Response to Influenza Infection.
- Liver-primed CD8(+) T cells suppress antiviral adaptive immunity through galectin-9-independent T-Cell immunoglobulin and mucin 3 engagement of high-mobility group box...
- Distinct Dendritic Cell Subsets Dictate the Fate Decision between Effector and Memory CD8(+) T Cell Differentiation by a CD24-Dependent Mechanism.
- Cytokine-Dependent Induction of CD4+ T cells with Cytotoxic Potential during Influenza Virus Infection.
- Immunity to viruses.
- Group 2 Innate Lymphoid Cell Production of IL-5 Is Regulated by NKT Cells during Influenza Virus Infection.
- Role of T cell immunity in recovery from influenza virus infection.
- Viral infection of the lung: Host response and sequelae.
- Influenza-Infected Neutrophils within the Infected Lungs Act as Antigen Presenting Cells for Anti-Viral CD8(+) T Cells.
- Recent insights into pulmonary repair following virus-induced inflammation of the respiratory tract.
- Pathogenesis of rhinovirus infection.
- Slowing down with age: lung DCs do it too.
- MHC Class II Expression and Hemagglutinin Subtype Influence the Infectivity of Type A Influenza Virus for Respiratory Dendritic Cells.
- Autocrine Regulation of Pulmonary Inflammation by Effector T-Cell Derived IL-10 during Infection with Respiratory Syncytial Virus.
- CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs.
- Antiviral CD8+ T cell effector activities in situ are regulated by target cell type.
- Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection.
- Stimulation of naive CD8+ T cells by a variant viral epitope induces activation and enhanced apoptosis.
- The cell cycle time of CD8+ T cells responding in vivo is controlled by the type of antigenic stimulus.
- Pulmonary eosinophilia is attenuated by early responding CD8(+) memory T cells in a murine model of RSV vaccine-enhanced disease.
- Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10.
- Respiratory dendritic cell subsets differ in their capacity to support the induction of virus-specific cytotoxic CD8+ T cell responses.
- RSV 2007: recent advances in respiratory syncytial virus research.
- Differential response of respiratory dendritic cell subsets to influenza virus infection.
- Proliferative expansion and acquisition of effector activity by memory CD4+ T cells in the lungs following pulmonary virus infection.
- Sequential activation of CD8+ T cells in the draining lymph nodes in response to pulmonary virus infection.
- Comparative activities of oseltamivir and A-322278 in immunocompetent and immunocompromised murine models of influenza virus infection.
- Preferential migration of effector CD8+ T cells into the interstitium of the normal lung.
- Lymph node dendritic cells control CD8+ T cell responses through regulated FasL expression.
- Transient loss of MHC class I tetramer binding after CD8+ T cell activation reflects altered T cell effector function.
- Frequency, specificity, and sites of expansion of CD8+ T cells during primary pulmonary influenza virus infection.
- Respiratory syncytial virus and T cells: interplay between the virus and the host adaptive immune system.
- Vbeta14(+) T cells mediate the vaccine-enhanced disease induced by immunization with respiratory syncytial virus (RSV) G glycoprotein but not with formalin-inactivated...
- Activation, differentiation, and migration of naive virus-specific CD8+ T cells during pulmonary influenza virus infection.
- Improved effector activity and memory CD8 T cell development by IL-2 expression during experimental respiratory syncytial virus infection.
- LFA-1 is required for retention of effector CD8 T cells in mouse lungs.
- Accelerated migration of respiratory dendritic cells to the regional lymph nodes is limited to the early phase of pulmonary infection.
- RSV-induced immunopathology: dynamic interplay between the virus and host immune response.
- Respiratory syncytial virus infection suppresses lung CD8+ T-cell effector activity and peripheral CD8+ T-cell memory in the respiratory tract.
- The adaptive immune response to respiratory syncytial virus.
- Immune surveillance by rhinovirus-specific circulating CD4+ and CD8+ T lymphocytes.
- The analysis of the monoclonal immune response to influenza virus. I. Production of monoclonal anti-viral antibodies in vitro.
- Role of T-cell function in recovery from murine influenza infection.
- Immunologic recognition of influenza virus-infected cells. II. Expression of influenza A matrix protein on the infected cell surface and its role in recognition by cro...
- Immunologic recognition of influenza virus-infected cells. I. Generation of a virus-strain specific and a cross-reactive subpopulation of cytotoxic T cells in the resp...
- Role of viral infectivity in the induction of influenza virus-specific cytotoxic T cells.
- Specificity of cytotoxicity T cells directed to influenza virus hemagglutinin.
- Functional and structural considerations in the recognition of virus-infected cells by cytotoxic T lymphocytes.
- Human neurolymphomatosis.
- Analysis of the humoral immune response to influenza virus in vitro.
- Infectious Sindbis virus transient expression vectors for studying antigen processing and presentation.
- CD8+ T cell recognition of an endogenously processed epitope is regulated primarily by residues within the epitope.
- Antigen processing for presentation by MHC class I molecules.
- Viral antigen presentation and MHC assembly.
- The recognition of a viral antigenic moiety by class I MHC-restricted cytolytic T lymphocytes is limited by the availability of the endogenously processed antigen.
- Antigen presentation: structural themes and functional variations.
- Recognition of the influenza hemagglutinin by class II MHC-restricted T lymphocytes and antibodies. I. Site definition and implications for antigen presentation and T ...
- Presentation of viral antigen to class I major histocompatibility complex-restricted cytotoxic T lymphocyte. Recognition of an immunodominant influenza hemagglutinin s...
- Nonconventional (TL-encoded) major histocompatibility complex molecules present processed viral antigen to cytotoxic T lymphocytes.
- Expression of specific cytolytic activity by H-2I region-restricted, influenza virus-specific T lymphocyte clones.
- Stable expression of cytolytic activity by influenza virus-specific cytotoxic T lymphocytes.
- Expression of H-2I region-restricted cytolytic activity by an Lyt-2+ influenza virus-specific T lymphocyte clone.
- Fine specificity and antigen receptor expression among influenza virus-specific cytolytic T lymphocyte clones.
- Expression of a murine polyclonal T cell receptor marker correlates with the use of specific members of the V beta 8 gene segment subfamily.
- Characterization and in vivo distribution of influenza-virus-specific T-lymphocytes in the murine respiratory tract.
- On the role of the transmembrane anchor sequence of influenza hemagglutinin in target cell recognition by class I MHC-restricted, hemagglutinin-specific cytolytic T ly...
- Antigen presentation pathways to class I and class II MHC-restricted T lymphocytes.
- Antigen form influences induction and frequency of influenza-specific class I and class II MHC-restricted cytolytic T lymphocytes.
- Class I MHC-restricted recognition of cells expressing a gene encoding a 41 amino acid product of the influenza hemagglutinin.
- Class I major histocompatibility complex-restricted cytolytic T lymphocytes recognize a limited number of sites on the influenza hemagglutinin.
- Class I major histocompatibility complex-restricted T lymphocyte recognition of the influenza hemagglutinin. Overlap between class I cytotoxic T lymphocytes and antibo...
- Recognition of pre-processed endogenous antigen by class I but not class II MHC-restricted T cells.
- Cytotoxic T lymphocytes recognize a cross-reactive epitope on the transmembrane region of influenza H1 and H2 hemagglutinins.
- T-lymphocyte recognition of a membrane glycoprotein.
- Regulation of T lymphocyte proliferation. Interleukin 2-mediated induction of c-myb gene expression is dependent on T lymphocyte activation state.
- Anti-T cell receptor antibodies fail to inhibit specific lysis by CTL clones but activate lytic activity for irrelevant targets.
- Distinguishable pathways of viral antigen presentation to T lymphocytes.
- Differences in antigen presentation to MHC class I-and class II-restricted influenza virus-specific cytolytic T lymphocyte clones.
- Features of target cell lysis by class I and class II MHC-restricted cytolytic T lymphocytes.
- Xyloside inhibits synthesis of the class II-associated chondroitin sulfate proteoglycan and antigen presentation events.
- Activation of virus specific CTL clones: antigen-dependent regulation of interleukin 2 receptor expression.
- Heterogeneity and specificity of cloned lines of influenza-virus specific cytotoxic T lymphocytes.
- Simultaneous expression of H-2-restricted and alloreactive recognition by a cloned line of influenza virus-specific cytotoxic T lymphocytes.
- Antigen-dependent proliferation of cloned continuous lines of H-2-restricted influenza virus-specific cytotoxic T lymphocytes.
- Target-cell recognition by cloned lines of influenza virus-specific cytotoxic T lymphocytes. Selective inhibition by a monoclonal H-2-specific antibody.
- Cytotoxic T lymphocyte recognition of the influenza hemagglutinin gene product expressed by DNA-mediated gene transfer.
- Antigen-dependent regulation of interleukin 2 receptor expression on cloned human cytotoxic T lymphocytes.
- In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific.
- Influenza virus-specific human cytotoxic T cell clones: heterogeneity in antigenic specificity and restriction by class II MHC products.
- Sendai virus-specific, H-2-restricted cytotoxic T lymphocyte responses of nude mice grafted with allogeneic or semi-allogeneic thymus glands.
- Macrophage procoagulant-inducing activity of influenza-specific effector T cells.
- Mycoplasma infection of cell cultures: thymidine incorporation of culture supernatants as a screening test.
- Regulation of interleukin 2 receptor expression on murine cytotoxic T lymphocyte clones.
- MIs locus recognition by a cloned line of H-2-restricted influenza virus-specific cytotoxic T lymphocytes.
- A helper factor needed for the generation of mouse cytolytic T lymphocytes is made by tumor cell lines, cloned T cells, and spleen cells exposed to a variety of stimuli.
Schools
Perelman School of Medicine University of Pennsylvania
Doctors Specialties
- Immunology
- Allergy
Accepted Insurances
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