Physician

Pathology

Timothy McDonnell practices Pathology. He went to Washington University School of Medicine in St. Louis. Timothy McDonnell is a published physician. He has 50 papers published. The most current publication "ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies." He accepts Medicare.

Publications

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• Clinical features, tumor biology, and prognosis associated with MYC rearrangement and Myc overexpression in diffuse large B-cell lymphoma patients treated with rituxim...
• Rearrangements of MYC gene facilitate risk stratification in diffuse large B-cell lymphoma patients treated with rituximab-CHOP.
• Metastatic splenic angiosarcoma presenting with thrombocytopenia and bone marrow fibrosis mimicking idiopathic thrombocytopenic purpura and primary myelofibrosis: a di...
• Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis.
• Therapy-related myeloid neoplasms following fludarabine, cyclophosphamide, and rituximab (FCR) treatment in patients with chronic lymphocytic leukemia/small lymphocyti...
• PI3 Kinase inhibition on TRAIL-induced apoptosis correlates with androgen-sensitivity and p21 expression in prostate cancer cells.
• The E1B19K Oncoprotein Complexes with Beclin 1 to Regulate Autophagy in Adenovirus-Infected Cells.
• Chemotherapy-associated recurrent pneumothoraces in lymphangioleiomyomatosis.
• The RB-E2F1 pathway regulates autophagy.
• HDM4 is overexpressed in mantle cell lymphoma and its inhibition induces p21 expression and apoptosis.
• The p53 tumor suppressor network in cancer and the therapeutic modulation of cell death.
• Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer.
• Bilateral olecranon fracture as first presentation of sarcoidosis: case report and review of the literature.
• Cooperation of Ha-ras and Bcl-2 during multistep skin carcinogenesis.
• Dicarbonyl/L-xylulose reductase: a potential biomarker identified by laser-capture microdissection-micro serial analysis of gene expression of human prostate adenocarc...
• The sonic hedgehog signaling network in development and neoplasia.
• Initial modulation of the tumor microenvironment accounts for thalidomide activity in prostate cancer.
• HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblastic leukemia and is a potential therapeutic target.
• Identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repression.
• Bcl-2 and bax expression and prostate cancer outcome in men treated with radiotherapy in Radiation Therapy Oncology Group protocol 86-10.
• Effectiveness of pulmonary rehabilitation in restrictive lung disease.
• Changes in serum proteomic patterns by presurgical alpha-tocopherol and L-selenomethionine supplementation in prostate cancer.
• Protein expression of a triad of frequently methylated genes, p73, p57Kip2, and p15, has prognostic value in adult acute lymphocytic leukemia independently of its meth...
• Combined laser capture microdissection and serial analysis of gene expression from human tissue samples.
• Sonic hedgehog induces epidermal growth factor dependent matrix infiltration in HaCaT keratinocytes.
• Clinical and biomarker correlates of androgen-independent, locally aggressive prostate cancer with limited metastatic potential.
• Prognostic value of P53, MDM-2, and MUC-1 for patients with inflammatory breast carcinoma.
• MCL-1 expression in B-cell non-Hodgkin's lymphomas.
• mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways.
• Evidence that transfer of functional p53 protein results in increased apoptosis in prostate cancer.
• Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1.
• Caspase-3 activation in systemic anaplastic large-cell lymphoma.
• Translation inhibitors sensitize prostate cancer cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by activating c-Jun N-te...
• Characterization of 4 mantle cell lymphoma cell lines.
• Regulation of Bcl-2 expression by dihydrotestosterone in hormone sensitive LNCaP-FGC prostate cancer cells.
• Epidermal growth factor receptor, cyclooxygenase-2, and BAX expression in the primary non-small cell lung cancer and brain metastases.
• Expression of p27(Kip1) and c-Jun activation binding protein 1 are inversely correlated in systemic anaplastic large cell lymphoma.
• Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy.
• BCL-2 expression in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease predicts a poorer prognosis in patients treated with ABVD or equivalent regimens.
• Apoptotic rate in peripheral T-cell lymphomas. A study using a tissue microarray with validation on full tissue sections.
• Evidence that nucleotide excision repair is attenuated in bax-deficient mammalian cells following ultraviolet irradiation.
• Association of Ki-67, p53, and bcl-2 expression of the primary non-small-cell lung cancer lesion with brain metastatic lesion.
• Overexpression of Mcl-1 in anaplastic large cell lymphoma cell lines and tumors.
• The application of molecular techniques to solid tumors.
• Hepatocyte growth factor/scatter factor binds to small heparin-derived oligosaccharides and stimulates the proliferation of human HaCaT keratinocytes.
• A recombinant adenovirus expressing wild-type Bax induces apoptosis in prostate cancer cells independently of their Bcl-2 status and androgen sensitivity.
• The association of p21((WAF-1/CIP1)) with progression to androgen-independent prostate cancer.
• BAX expression in Hodgkin and Reed-Sternberg cells of Hodgkin's disease: correlation with clinical outcome.
• ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies.

Schools

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• Washington Center School of Medicine

Doctors Specialties

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• Anatomic Pathology
• Pathology

Accepted Insurances

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• Choice Plus POS II
• Cigna HMO
• Cigna PPO
• Great West Healthcare-Cigna PPO
• LocalPlus
• Open Access Plus
• Commercial Insurance Company
• Emblem Health
• Medicare MCR
• MultiPlan PPO
• PHCS Network PPO
• Choice Plus POS
• Navigate HMO
• Navigate POS
• Options PPO
• United Healthcare

Education

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• Washington University - Barnes-Jewish Hospital
• Washington University School of Medicine in St. Louis

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