Professor, Medicine, UCSF School of Medicine
Pathology
Dr. Yuet W. Kan, MD
Yuet practices Pathology. He has 3 awards "Elected Member", "Investigator Alumnus" and "Whos Who in Medicine and Healthcare". Yuet is also a published doctor. He has 101 paper published. The most recent paper is: Enzymatic reaction with unnatural substrates: DNA photolyase (Escherichia coli) recognizes and reverses thymine [2+2] dimers in the DNA strand of a DNA/PNA hybrid duplex.
Publications
- Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac.
- Blood cell-derived induced pluripotent stem cells free of reprogramming factors generated by Sendai viral vectors.
- Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoter.
- Coexpression of VEGF and angiopoietin-1 promotes angiogenesis and cardiomyocyte proliferation reduces apoptosis in porcine myocardial infarction (MI) heart.
- Generation of induced pluripotent stem cells using site-specific integration with phage integrase.
- Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice.
- Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases.
- Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte.
- Permanent coronary artery occlusion: cardiovascular MR imaging is platform for percutaneous transendocardial delivery and assessment of gene therapy in canine model.
- High oxygen environment during pregnancy rescues sickle cell anemia mice from prenatal death.
- Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage.
- Adeno-associated viral vector-delivered hypoxia-inducible gene expression in ischemic hearts.
- Yuet Wai Kan, MD: sickle cell and thalassemia pioneer. Interview by Tracy Hampton.
- Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice.
- Correction of the sickle cell mutation in embryonic stem cells.
- Recombinant adeno-associated viral vector encoding human VEGF165 induces neomicrovessel formation in the adult mouse brain.
- The binding of the ubiquitous transcription factor Sp1 at the locus control region represses the expression of beta-like globin genes.
- Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription.
- Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts.
- Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia.
- Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microa...
- Adeno-associated viral vector-mediated gene transfer of VEGF normalizes skeletal muscle oxygen tension and induces arteriogenesis in ischemic rat hindlimb.
- Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation.
- Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound.
- Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model.
- Globin structural mutant alpha 125Leu leads to Pro is a novel cause of alpha-thalassaemia.
- Construction of a functional human suppressor tRNA gene: an approach to gene therapy for beta-thalassaemia.
- Long-distance charge transport in duplex DNA: the phonon-assisted polaron-like hopping mechanism.
- Enzymatic reaction with unnatural substrates: DNA photolyase (Escherichia coli) recognizes and reverses thymine [2+2] dimers in the DNA strand of a DNA/PNA hybrid duplex.
- Direct isolation of the functional human thymidine kinase gene with a cosmid shuttle vector.
- Construction of human chromosome 21-specific yeast artificial chromosomes.
- A new protein synthesis factor from Escherichia coli.
- Chromosomal localization of the human apolipoprotein B gene and detection of homologous RNA in monkey intestine.
- In vivo aminoacylation of human and Xenopus suppressor tRNAs constructed by site-specific mutagenesis.
- Cloning of a cDNA for steroid sulfatase: frequent occurrence of gene deletions in patients with recessive X chromosome-linked ichthyosis.
- Molecular basis of hereditary elliptocytosis due to protein 4.1 deficiency.
- Survival of a hydropic infant with homozygous alpha-thalassemia-1.
- The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling.
- 5-Azacytidine treatment in a beta (0)-thalassaemic patient unable to be transfused due to multiple alloantibodies.
- Alpha-thalassemia in blacks is due to gene deletion.
- Effects of celecoxib and nimesulide on the proliferation of ectopic endometrial stromal cells in vitro.
- Expression of steroidogenic factor 1 (SF-1) and steroidogenic acute regulatory protein (StAR) in endometriosis is associated with endometriosis severity.
- Diagnosis of spinal muscular atrophy from fetal normoblasts in maternal blood.
- Ferrara beta 0 thalassaemia caused by the beta 39 nonsense mutation.
- Sequence of the 3''-noncoding and adjacent coding regions of human gamma-globin mRNA.
- Mild thalassemia: the result of interactions of alpha and beta thalassemia genes.
- Two types of triplicated alpha-globin loci in humans.
- Molecular pathology of alpha-thalassemia.
- Cosmid vectors for high efficiency DNA-mediated transformation and gene amplification in mammalian cells: studies with the human growth hormone gene.
- Assignment of the human casein kinase II beta-subunit gene to 6p12----p21.
- Beta thalassemia in Sardinia in the result of a nonsense mutation.
- Genetic lesion in homozygous alpha thalassaemia (hydrops fetalis).
- alpha-Globin gene organisation in blacks precludes the severe form of alpha-thalassaemia.
- Origin of "fused" glucose-6-phosphate dehydrogenase.
- Molecular characterization of erythrocyte glycophorin C variants.
- Long survival in sickle cell anemia.
- Detection of sickle cell anaemia mutation by colour DNA amplification.
- Butyrate analogues modulate globin gene expression in human and ovine erythroid cells.
- Haemoglobin Constant Spring synthesis in red cell precursors.
- Equal synthesis of - and -globin chains in erythroid precursors in heterozygous -thalassemia.
- Unbalanced globin chain synthesis in alpha-thalassemia heterozygotes.
- Cellular regulation of fetal hemoglobin synthesis in man. Investigation of gamma and beta mRNA accumulation in clonal erythroid cultures initiated from erythroid proge...
- A novel beta-thalassemia frameshift mutation (codon 14/15), detectable by direct visualization of abnormal restriction fragment in amplified genomic DNA.
- A rapid and simple electrophoretic method for the detection of mutations involving small insertion or deletion: application to beta-thalassemia.
- A rapid screening test for antenatal sex determination.
- Evolution of the hemoglobin S and C genes in world populations.
- Globin chain synthesis in the alpha thalassemia syndromes.
- Spontaneous mutation in beta-thalassaemia producing the same nucleotide substitution as that in a common hereditary form.
- Detection of cytomegalovirus infection in paraffin-embedded tissue specimens with the polymerase chain reaction.
- Hemoglobin abnormalities: molecular and evolutionary studies.
- alpha-Thalassemia caused by an unstable alpha-globin mutant.
- Expression and function of suppressor tRNA genes in mammalian cells.
- Gamma-beta thalassemia: a cause of hemolytic disease of the newborn.
- Inhibition of hemoglobin synthesis by cyanate in vitro.
- Fetal blood sampling in midtrimester pregnancies.
- Prenatal diagnosis of hemoglobin H disease.
- Localization of the gene for coagulation factor XIII a-chain to chromosome 6 and identification of sites of synthesis.
- Effects of cyanate and 2,3-diphosphoglycerate on sickling. Relationship to oxygenation.
- Modification of hemoglobin H disease by sickle trait.
- Isolation of hybrid cell clones that contain deletion and non-deletion defects of alpha-thalassemia in man.
- Hydrops fetalis due to an unusual form of Hb H disease.
- Prenatal diagnosis of homozygous beta-thalassaemia.
- Intrauterine diagnosis of thalassemia.
- Fetal blood-sampling in utero.
- Platelet glycoprotein IIb. Chromosomal localization and tissue expression.
- Alpha globin gene number: population and restriction endonuclease studies.
- Organization of the zeta-alpha genes in Chinese.
- Prenatal diagnosis of hemoglobin disorders.
- Identification of a nondeletion defect in alpha-thalassemia.
- Differentiation of the mRNA transcripts originating from the alpha 1- and alpha 2-globin loci in normals and alpha-thalassemics.
- Molecular mechanisms in alpha thalassemia: racial differences in alpha-globin gene organization.
- The molecular defects of alpha-thalassemia in the Filipino.
- Detection of sickle cell anaemia and thalassaemias.
- Diagnosis of homozygous alpha-thalassemia in cultured amniotic-fluid fibroblasts.
- A simple sensitive prenatal test for hydrops fetalis caused by alpha-thalassaemia.
- Stopping the biologic clock for globin gene switching.
- Butyric acid modulates developmental globin gene switching in man and sheep.
- BamH I polymorphism in the Chinese: its potential usefulness in prenatal diagnosis of beta thalassaemia.
- Characteristics and distribution of beta thalassemia haplotypes in South China.
- Suppression of the nonsense mutation in homozygous beta 0 thalassaemia.
Doctors Specialties
- Other
- Pathology
Accepted Insurances
Awards
- Elected Member
- Investigator Alumnus
- Whos Who in Medicine and Healthcare
Education
-
University of Pittsburgh Medical Center -
Brigham and Women's Hospital -
University of Hong Kong Faculty of Medicine
Hospital
-
UCSF Medical Center
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