Professor, Medicine, USC School of Medicine
Internal Medicine
Dr. Zea Borok, MD
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Borok practices Internal Medicine. She received awards:"Super Doctor". Borok is also a published MD. She has 102 paper published. The most recent paper is: Modulation of t1alpha expression with alveolar epithelial cell phenotype in vitro.
Publications
- Non-canonical WNT signalling in the lung.
- A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland.
- Transcriptomic Profiling of Primary Alveolar Epithelial Cell Differentiation in Human and Rat.
- Progenitors of Secondary Crest Myofibroblasts are Developmentally Committed in Early Lung Mesoderm.
- Alveolar epithelium: beyond the barrier.
- Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis.
- Future Directions in Idiopathic Pulmonary Fibrosis Research: An NHLBI Workshop Report.
- Deletion of ATG5 Shows a Role of Autophagy in Salivary Homeostatic Control.
- Integrated transcriptomic and epigenomic analysis of primary human lung epithelial cell differentiation.
- Apc deficiency alters Pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling.
- Nanoparticle translocation across mouse alveolar epithelial cell monolayers: Species-specific mechanisms.
- Aqp5 is a new transcriptional target of dot1a and a regulator of aqp2.
- EMT and interstitial lung disease: a mysterious relationship.
- Troglitazone attenuates TGF-β1-induced EMT in alveolar epithelial cells via a PPARγ-independent mechanism.
- NOTCH1 Is Required for Regeneration of Clara Cells During Repair of Airway Injury.
- Cigarette smoke extract stimulates epithelial-mesenchymal transition through Src activation.
- Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue.
- Tissue-Dependent Consequences of Apc Inactivation on Proliferation and Differentiation of Ciliated Cell Progenitors via Wnt and Notch Signaling.
- Translocation of PEGylated quantum dots across rat alveolar epithelial cell monolayers.
- Ligand-independent transforming growth factor-β type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition.
- In search of the fibrotic epithelial cell: opportunities for a collaborative network.
- Stem cells and cell therapies in lung biology and lung diseases.
- Cell Plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010.
- Polystyrene nanoparticle trafficking across MDCK-II.
- Role of ER Stress in EMT of Alveolar Epithelial Cells: Effects of Misfolded Surfactant Protein.
- Epithelium-specific deletion of TGF-? receptor type II protects mice from bleomycin-induced Pulmonary fibrosis.
- Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses Pulmonary fibrosis.
- Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair.
- Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure.
- Signaling via Alk5 controls the ontogeny of lung Clara cells.
- More life for a "terminal" cell.
- Directed expression of Cre in alveolar epithelial type 1 cells.
- Epithelial-mesenchymal transition: potential role in obliterative bronchiolitis?
- N-acetylcysteine inhibits alveolar epithelial-mesenchymal transition.
- Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles.
- Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury.
- Characterization of mouse alveolar epithelial cell monolayers.
- Conjugation with cationic cell-penetrating peptide increases Pulmonary absorption of insulin.
- Role for alpha3 integrin in EMT and Pulmonary fibrosis.
- Mesodermal deletion of transforming growth factor-beta receptor II disrupts lung epithelial morphogenesis: cross-talk between TGF-beta and Sonic hedgehog pathways.
- Progressive recruitment of Runx2 to genomic targets despite decreasing expression during osteoblast differentiation.
- GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1.
- Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury.
- Rat aquaporin-5 4.3-kb 5'-flanking region differentially regulates expression in salivary gland and lung in vivo.
- Characterization of protein factor(s) in rat bronchoalveolar lavage fluid that enhance insulin transport via transcytosis across primary rat alveolar epithelial cell m...
- Polystyrene nanoparticle trafficking across alveolar epithelium.
- Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain.
- SMAD3 prevents binding of NKX2.1 and FOXA1 to the SpB promoter through its MH1 and MH2 domains.
- Functional characterization and cloning of amino acid transporter B(0,+) (ATB(0,+)) in primary cultured rat pneumocytes.
- Expression and biological activity of ABCA1 in alveolar epithelial cells.
- Effects of KGF on alveolar epithelial cell transdifferentiation are mediated by JNK signaling.
- Molecular and functional expression of multidrug resistance-associated protein-1 in primary cultured rat alveolar epithelial cells.
- TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease.
- Nanoparticle effects on rat alveolar epithelial cell monolayer barrier properties.
- Enhancement of insulin transport across primary rat alveolar epithelial cell monolayers by endogenous cellular factor(s).
- Endothelin-1 induces alveolar epithelial-mesenchymal transition through endothelin type A receptor-mediated production of TGF-beta1.
- Conserved elements within first intron of aquaporin-5 (Aqp5) function as transcriptional enhancers.
- Transcriptional regulation by targeted expression of architectural transcription factor high mobility group A2 in salivary glands of transgenic mice.
- Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells.
- Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alpha.
- Epithelial origin of myofibroblasts during fibrosis in the lung.
- SUMOylation attenuates sensitivity toward hypoxia- or desferroxamine-induced injury by modulating adaptive responses in salivary epithelial cells.
- Adult stem cells, lung biology, and lung disease. NHLBI/Cystic Fibrosis Foundation Workshop.
- Developmental pathways and specification of intraPulmonary stem cells.
- Development of a lung slice preparation for recording ion channel activity in alveolar epithelial type I cells.
- Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic Pulmonary fibrosis.
- Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cells.
- Estimation of paracellular conductance of primary rat alveolar epithelial cell monolayers.
- Net absorption of IgG via FcRn-mediated transcytosis across rat alveolar epithelial cell monolayers.
- Alveolar epithelial type I cells express beta2-adrenergic receptors and G-protein receptor kinase 2.
- Subunit-specific coordinate upregulation of sodium pump activity in alveolar epithelial cells by lentivirus-mediated gene transfer.
- Suppression of the transformed phenotype and induction of differentiation-like characteristics in cultured ovarian tumor cells by chronic treatment with progesterone.
- Timeless in lung morphogenesis.
- Role of f-box factor foxj1 in differentiation of ciliated airway epithelial cells.
- Modulation of ion conductance and active transport by TGF-beta 1 in alveolar epithelial cell monolayers.
- Identification of three genes of known function expressed by alveolar epithelial type I cells.
- Lung Edema clearance: 20 years of progress: invited review: role of aquaporin water channels in fluid transport in lung and airways.
- Wnt5a participates in distal lung morphogenesis.
- Hypoxia decreases active Na transport across primary rat alveolar epithelial cell monolayers.
- Na transport proteins are expressed by rat alveolar epithelial type I cells.
- Re-evaluating the Na(+) conductance of adult rat alveolar type II pneumocytes: evidence for the involvement of cGMP-activated cation channels.
- Vesicular stomatitis virus G-pseudotyped lentivirus vectors mediate efficient apical transduction of polarized quiescent primary alveolar epithelial cells.
- Extracellular glutathione inhibits oxygen-induced permeability changes in alveolar epithelial monolayers.
- A useful in vitro model for transport studies of alveolar epithelial barrier.
- 4-Hydroxy-2-nonenal increases gamma-glutamylcysteine synthetase gene expression in alveolar epithelial cells.
- Integrin alpha(3)-subunit expression modulates alveolar epithelial cell monolayer formation.
- Differential regulation of rat aquaporin-5 promoter/enhancer activities in lung and salivary epithelial cells.
- Epidermal growth factor regulation in adult rat alveolar type II cells of amiloride-sensitive cation channels.
- Glutathione aerosol suppresses lung epithelial surface inflammatory cell-derived oxidants in cystic fibrosis.
- KGF prevents hyperoxia-induced reduction of active ion transport in alveolar epithelial cells.
- Modulation of t1alpha expression with alveolar epithelial cell phenotype in vitro.
- Mechanisms of EGF-induced stimulation of sodium reabsorption by alveolar epithelial cells.
- Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin 5.
- Na(+)-K(+)-ATPase expression in alveolar epithelial cells: upregulation of active ion transport by KGF.
- Identification of Na(+)-K(+)-ATPase beta-subunit in alveolar epithelial cells.
- Effects of EGF on alveolar epithelial junctional permeability and active sodium transport.
- Activation of alveolar macrophages in asymptomatic HIV-infected individuals.
- Pulmonary Langerhans cell granulomatosis (histiocytosis X). A clinicopathologic study of 48 cases.
- Correction of glutathione deficiency in the lower Respiratory tract of HIV seropositive individuals by glutathione aerosol treatment.
- Systemic deficiency of glutathione in cystic fibrosis.
- p300/β-catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of Wnt5a/Protein Kinase C (PKC).
Schools
University Of Cape Town Faculty Of Health Sciences
Groote Schuur Hospital
Fell University Pittsburgh
Montefiore Hospital
National Institute Of Health
Procedures Preformed
- Ventilation Management
Conditions Treated
- Pulmonary Edema
- Respiratory Failure
Doctors Specialties
- Critical Care Medicine
- Pulmonology
- Internal Medicine
Accepted Insurances
Awards
- Super Doctor
Education
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National Institutes of Health Clinical Center -
University of Pittsburgh Medical Center -
University of Cape Town Faculty of Medicine
Hospital
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Keck Hospital of USC
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